User:JonSDSUGrad/Sandbox/Demo dIGFBP1

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Insulin-like growth factor binding protein 1

PDB rendering based on 1zt3.

Available structures: 1zt3, 1zt5, 2dsq

Identifiers

Symbol(s)

IGFBP1; IBP1; AFBP; IGF-BP25; PP12; hIGFBP-1

External IDs

OMIM: 146730 MGI: 96436 HomoloGene: 498

Gene ontology
Molecular Function:	• insulin-like growth factor binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• regulation of cell growth • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000596 (mRNA)
NP_000587 (protein)

NM_008341 (mRNA)
NP_032367 (protein)

Location

Chr 7: 45.89 - 45.9 Mb

Chr 11: 7.1 - 7.1 Mb

Pubmed search

[1]

[2]

Insulin-like growth factor binding protein 1, also known as IGFBP1, is a human gene.^[1]

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1.

[edit] Further reading

Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish.". Int. Rev. Cytol. 243: 215-85. doi:10.1016/S0074-7696(05)43004-1. PMID 15797461.
Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins.". Endocr. Rev. 23 (6): 824-54. PMID 12466191.
Ferry RJ, Cerri RW, Cohen P (1999). "Insulin-like growth factor binding proteins: new proteins, new functions.". Horm. Res. 51 (2): 53-67. PMID 10352394.
Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.". Endocr. Rev. 18 (6): 801-31. PMID 9408744.
Subramanian A, Sharma AK, Banerjee D, et al. (2007). "Evidence for a tumour suppressive function of IGF1-binding proteins in human breast cancer.". Anticancer Res. 27 (5B): 3513-8. PMID 17972510.
Li ZQ, Yu WP, Xie XD, et al. (2007). "Association of gastric cancer with tyrosine hydroxylase gene polymorphism in a northwestern Chinese population.". Clin. Exp. Med. 7 (3): 98-101. doi:10.1007/s10238-007-0135-x. PMID 17972051.
Pechlivanis S, Pardini B, Bermejo JL, et al. (2008). "Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect.". Endocr. Relat. Cancer 14 (3): 733-40. doi:10.1677/ERC-07-0107. PMID 17914103.
Tworoger SS, Mantzoros C, Hankinson SE (2008). "Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels.". Obesity (Silver Spring) 15 (9): 2217-24. PMID 17890489.
Berg U, Bang P, Carlsson-Skwirut C (2007). "Calpain proteolysis of insulin-like growth factor binding protein (IGFBP) -2 and -3, but not of IGFBP-1.". Biol. Chem. 388 (8): 859-63. doi:10.1515/BC.2007.098. PMID 17655506.
Magne L, Blanc E, Marchand A, et al. (2008). "Stabilization of IGFBP-1 mRNA by ethanol in hepatoma cells involves the JNK pathway.". J. Hepatol. 47 (5): 691-8. doi:10.1016/j.jhep.2007.05.018. PMID 17640761.
Smith P, Nicholson LJ, Syed N, et al. (2007). "Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes.". Clin. Cancer Res. 13 (14): 4061-8. doi:10.1158/1078-0432.CCR-06-3052. PMID 17634530.
Cheng I, DeLellis Henderson K, Haiman CA, et al. (2007). "Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population.". J. Clin. Endocrinol. Metab. 92 (9): 3660-6. doi:10.1210/jc.2007-0790. PMID 17566087.
Oishi Y, Ohnishi M, Kobayashi-Hattori K, et al. (2007). "Cadmium cation increases the production and mRNA levels of insulin-like growth factor-binding protein-1 in HepG2.". Biosci. Biotechnol. Biochem. 71 (5): 1334-7. PMID 17485842.
Sato Y, Chen Z, Miyazaki K (2007). "Strong suppression of tumor growth by insulin-like growth factor-binding protein-related protein 1/tumor-derived cell adhesion factor/mac25.". Cancer Sci. 98 (7): 1055-63. doi:10.1111/j.1349-7006.2007.00502.x. PMID 17465992.
Schweizer-Groyer G, Fallot G, Cadepond F, et al. (2007). "The cAMP-responsive unit of the human insulin-like growth factor-binding protein-1 coinstitutes a functional insulin-response element.". Ann. N. Y. Acad. Sci. 1091: 296-309. doi:10.1196/annals.1378.075. PMID 17341623.
Tamimi RM, Cox DG, Kraft P, et al. (2007). "Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study.". Breast Cancer Res. 9 (1): R18. doi:10.1186/bcr1655. PMID 17300730.
Kaplan RC, McGinn AP, Pollak MN, et al. (2007). "Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke.". J. Clin. Endocrinol. Metab. 92 (4): 1319-25. doi:10.1210/jc.2006-1631. PMID 17264182.
Chen C, Freeman R, Voigt LF, et al. (2007). "Prostate cancer risk in relation to selected genetic polymorphisms in insulin-like growth factor-I, insulin-like growth factor binding protein-3, and insulin-like growth factor-I receptor.". Cancer Epidemiol. Biomarkers Prev. 15 (12): 2461-6. doi:10.1158/1055-9965.EPI-06-0541. PMID 17164371.
Brady G, O'Regan E, Miller I, et al. (2007). "Serum levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs), -1, -2, -3, in oral cancer.". International journal of oral and maxillofacial surgery 36 (3): 259-62. doi:10.1016/j.ijom.2006.09.009. PMID 17113753.
Degenhardt T, Matilainen M, Herzig KH, et al. (2007). "The insulin-like growth factor-binding protein 1 gene is a primary target of peroxisome proliferator-activated receptors.". J. Biol. Chem. 281 (51): 39607-19. doi:10.1074/jbc.M605623200. PMID 17062566.