Jonathan M. Rothberg
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Dr. Jonathan M. Rothberg was born in 1963 in New Haven, Connecticut. He earned a B.S. in chemical engineering with an option in Biomedical engineering from Carnegie Mellon University and an M.S., M.Phil, and Ph.D. in biology from Yale University.
Dr. Rothberg's team at 454 and the Baylor Genome center was the second to sequence an individual human genome (Jim Watson[1] [2]). While not yet peer-reviewed, that genome is publicly browsable via the efforts of Lincoln Stein's group [3] contributing significantly to the new field of personal genomics. The first individual human genome sequenced was that of Craig Venter [4][5].
Dr. Rothberg is the founder of 454 Life Sciences, CuraGen Corporation [6], Clarifi Corporation, The Rothberg Institute for Childhood Diseases, and the co-founder and Chairman of RainDance Technologies. Dr. Rothberg was named an Ernst and Young Entrepreneur of the Year and is the receipt of The Wall Street Journal’s Gold Medal for Innovation for his invention of 454 sequencing[citation needed], and The Irvington Institute’s Corporate Leadership Award in Science, and was selected by the World Economic Forum in 2007 [7] as a technology pioneer for the invention of 454 sequencing -- as well as in 2008 for Raindance Technologies[8]. Dr. Rothberg has appeared on CNBC for his pioneering work in the field of genomic medicine and his scientific work has been featured on the covers of leading scientific journals including Cell, Science, and Nature.
While at CuraGen Dr. Rothberg developed a series of new medicines, now in over 14 human clinical trials, for the treatment of a wide range of cancers. Dr. Rothberg’s invention of a new way to sequence DNA on a chip – 454 Sequencing, first motivated by his son’s visit to the emergency room, is a step toward personal medicine allowing sequencing of individuals and is now in use at major pharmaceutical companies, universities, genome centers, and medical centers around the world [9][10][11].
Dr. Rothberg is a member of the National Academy of Engineering, the Connecticut Academy of Science and Engineering, and serves on the board of trustees of Carnegie Mellon University. He initiated the Neanderthal Genome Project in collaboration with Svante Pääbo's group [12]
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[edit] References
- ^ http://www.bio-itworld.com/newsitems/2007/may/05-31-07-watson-genome Project Jim: Watson’s Personal Genome Goes Public
- ^ http://http://www.nytimes.com/2007/05/31/science/31cnd-gene.html?ex=1182139200&en=8c707c4f99236dd0&ei=5070 Genome of DNA Pioneer Is Deciphered
- ^ James Watson genotypes, on NCBI B36 assembly, dbSNP b126: chr7:75221807..75256264
- ^ Venter JC, et al. (2001). "The sequence of the human genome.". Science 291: 1304. doi:. PMID 11181995.
- ^ Levy S, Sutton G, Ng PC, Feuk L, Halpern AL, et al. (2007). "The Diploid Genome Sequence of an Individual Human". PLoS Biology 5 (10): e254. doi:.
- ^ CuraGen Corporation
- ^ http://www.weforum.org/documents/Newsletter/107/nl_1_07_en_seite6.html
- ^ World Economic Forum - Technology Pioneer Community
- ^ [http://www.nytimes.com/2005/08/01/health/01gene.html?ex=1280548800&en=31da11d54b6c2b4e&ei=5090&partner=rssuserland&emc=rss DNA Machine May Advance Genetic Sequencing for Patients
- ^ http://www.technologyreview.com/Biotech/18809/ The $2 Million Genome
- ^ http://www.nature.com/nature/journal/v437/n7057/abs/nature03959.html Genome sequencing in microfabricated high-density picolitre reactors
- ^ [http://www.nature.com/nature/journal/v444/n7117/abs/nature05336.html Analysis of one million base pairs of Neanderthal DNA
