John James Pringle

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John James Pringle (1855 – 1922-12-18) was a British dermatologist. He was born in Borgue, Kirkcudbrightshire in Scotland and educated at Merchiston Castle school. He graduated in medicine in 1876. He then travelled abroad, studying in Dublin, Vienna, Paris and Berlin before settling in London in 1882. From 1888 to 1920, we worked as a dermatologist at the Middlesex Hospital in London. He caught tuberculosis and spent six months of 1903 in a sanatorium. He never fully recovered and, whilst on a trip intended to improve his health, he died at Christchurch, New Zealand. He is related to Sir John Pringle.

Contents 1 Adenoma sebaceum 2 Achievements 3 Publications 4 See also 5 References 6 Further reading

[edit] Adenoma sebaceum

JJ Pringle is primarily remembered for the eponym: Pringle's Adenoma Sebaceum. Now known as facial angiofibroma, this papular facial rash, of distinctive butterfly distribution, was first described in English by Pringle. In 1890 he reported in detail the case of a 25 year old woman, who was not "particularly bright intellectually" and had presented with both skin and digestive complaints. He described the papules in detail, noting the capiliary involvement and their fibrous nature. He believed that the sebaceous glands were the source of the problem. Pringle was unfamiliar with the condition so presented his patient to a meeting of the Dermatological Society in 1889-01-09. Two visitors recognised a similarity with models in the Museum of the Saint Louis Hospital in Paris. This led Pringle to become acquainted with five other cases, two previously published, that he includes in his report.

Pringle adopted the term "adenoma sebaceum" from Félix Balzer's phrase "adénomes sébacés". The papules were in fact neither adenoma nor derived from sebaceous glands. Pringle dismisses one report of a hereditary aspect as "dubious". The patients are generally recultant to submit to treatment, which leads to considerable bleeding and pain.

Several years later, physicians would note the combination of adenoma sebaceum, epilepsy and idiocy was diagnosic for tuberous sclerosis. The three signs are known as Vogt's triad. Although Pringle's report does not mention epilepsy, most of the patients are of limited intelligence, and these cases are regarded as early accounts of tuberous sclerosis.

[edit] Achievements

• 1891–1895, editor of the British Journal of Dermatology.
• 1895–1901, secretary of the Dermatological Society.
• 1896, appointed Secretary General to the International Congress of Dermatology.
• President of the dermatology section of the Royal Society of Medicine

[edit] Publications

• Pringle, JJ (1890). "A case of congenital adenoma sebaceum". British Journal of Dermatology, Oxford 2: 1–14. 
• Pringle, JJ (1891). "Angiokeratoma". British Journal of Dermatology, Oxford 3: 237–244, 282–285, 309–317. 

[edit] See also

• Timeline of tuberous sclerosis

[edit] References

• Enersen, Ole Daniel. John James Pringle. Who Named It?. Retrieved on 2007-01-19.
• Jansen FE, van Nieuwenhuizen O, van Huffelen AC (2004). "Tuberous sclerosis complex and its founders". Journal of Neurology Neurosurgery and Psychiatry 75 (5): 770. doi:10.1136/jnnp.2003.027524. PMID 15090576. 
• Gold, Stephen. A Glimmering of Light. A Biographical History of British Dermatology. British Association of Dermatologists. Retrieved on 2007-02-02.

[edit] Further reading

• Lyell Alan (1985). "The man behind the eponym. John James Pringle (1855-1922)". The American Journal of Dermatopathology 7 (5): 441–5. PMID 3911795.