JMJD6

From Wikipedia, the free encyclopedia

Jumonji domain containing 6

Identifiers

JMJD6; KIAA0585; PSR; PTDSR; PTDSR1

External IDs

OMIM: 604914 MGI: 1858910 HomoloGene: 9046

Gene ontology
Molecular Function:	• receptor activity
Cellular Component:	• nucleus • plasma membrane
Biological Process:	• blood vessel development • apoptosis • cell surface receptor linked signal transduction • multicellular organismal development • heart development • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001081461 (mRNA)
NP_001074930 (protein)

NM_033398 (mRNA)
NP_203971 (protein)

Location

Chr 17: 72.22 - 72.23 Mb

Chr 11: 116.65 - 116.66 Mb

Pubmed search

[1]

[2]

Jumonji domain containing 6, also known as JMJD6, is a human gene.^[1]

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have suggested that the protein may cross-react with a monoclonal antibody that recognizes the phosphatidylserine receptor and does not directly function in the clearance of apoptotic cells. Multiple transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: JMJD6 jumonji domain containing 6.

[edit] Further reading

Williamson P, Schlegel RA (2005). "Hide and seek: the secret identity of the phosphatidylserine receptor.". J. Biol. 3 (4): 14. doi:10.1186/jbiol14. PMID 15453906.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581.
Fadok VA, Bratton DL, Rose DM, et al. (2000). "A receptor for phosphatidylserine-specific clearance of apoptotic cells.". Nature 405 (6782): 85–90. doi:10.1038/35011084. PMID 10811223.
Vandivier RW, Fadok VA, Hoffmann PR, et al. (2002). "Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis.". J. Clin. Invest. 109 (5): 661–70. PMID 11877474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ajmone-Cat MA, De Simone R, Nicolini A, Minghetti L (2003). "Effects of phosphatidylserine on p38 mitogen activated protein kinase, cyclic AMP responding element binding protein and nuclear factor-kappaB activation in resting and activated microglial cells.". J. Neurochem. 84 (2): 413–6. PMID 12559004.
Chan A, Seguin R, Magnus T, et al. (2003). "Phagocytosis of apoptotic inflammatory cells by microglia and its therapeutic implications: termination of CNS autoimmune inflammation and modulation by interferon-beta.". Glia 43 (3): 231–42. doi:10.1002/glia.10258. PMID 12898702.
Wang X, Wu YC, Fadok VA, et al. (2003). "Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.". Science 302 (5650): 1563–6. doi:10.1126/science.1087641. PMID 14645848.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cui P, Qin B, Liu N, et al. (2004). "Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals.". Exp. Cell Res. 293 (1): 154–63. PMID 14729065.
Cao WM, Murao K, Imachi H, et al. (2005). "Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells.". J. Mol. Endocrinol. 32 (2): 497–505. PMID 15072554.
Cikala M, Alexandrova O, David CN, et al. (2004). "The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity.". BMC Cell Biol. 5: 26. doi:10.1186/1471-2121-5-26. PMID 15193161.
Böse J, Gruber AD, Helming L, et al. (2005). "The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal.". J. Biol. 3 (4): 15. doi:10.1186/jbiol10. PMID 15345036.
Hong JR, Lin GH, Lin CJ, et al. (2004). "Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish.". Development 131 (21): 5417–27. doi:10.1242/dev.01409. PMID 15469976.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Köninger J, Balaz P, Wagner M, et al. (2005). "Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role.". Ann. Surg. 241 (1): 144–51. PMID 15622002.
Klose RJ, Kallin EM, Zhang Y (2006). "JmjC-domain-containing proteins and histone demethylation.". Nat. Rev. Genet. 7 (9): 715–27. PMID 16983801.
Chang B, Chen Y, Zhao Y, Bruick RK (2007). "JMJD6 is a histone arginine demethylase.". Science 318 (5849): 444–7. doi:10.1126/science.1145801. PMID 17947579.