Jeryl Lynn
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Jeryl Lynn are strains of mumps virus used in the Mumpsvax mumps vaccine made by Merck. The strains are named after Jeryl Lynn Hilleman. In 1963 Ms. Hilleman's father Dr. Maurice Hilleman, was leading efforts to produce a mumps vaccine for Merck. He cultured the Mumps virus from her throat, and in 1967 a vaccine was produced from this which is now widely used.[1]
The Jeryl Lynn strains used in the manufacture of Mumpsvax later turned out to contain two distinguishable viral substrains, JL1 and JL2.[2] Further research showed that the JL1 strain was preferentially selected by propagation in Vero and CEF cell cultures. The JL2 strain was preferentially selected by passage in embryonated chicken eggs.[3]
In the U.S.A. the Jeryl Lynn strain-based vaccines supplanted the previous, killed virus, vaccine in 1978.[1]
[edit] References
- ^ a b World Health Organization (March 1998). The Mumps Vaccine. Immunization, Vaccines and Biologicals. Retrieved on 2006-05-24.
- ^ Amexis G, Oeth P, Abel K, Ivshina A, Pelloquin F, Cantor C, Braun A, Chumakov K, Brau A (2001). "Quantitative mutant analysis of viral quasispecies by chip-based matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry.". Proc Natl Acad Sci U S A 98 (21): 12097–102. doi:. PMID 11593021.
- ^ Amexis G, Rubin S, Chizhikov V, Pelloquin F, Carbone K, Chumakov K (2002). "Sequence diversity of Jeryl Lynn strain of mumps virus: quantitative mutant analysis for vaccine quality control.". Virology 300 (2): 171–9. doi:. PMID 12350348.
- Complete genome of JL1 - Amexis,G., Rubin,S., Chizhikov,V., Pelloquin,F., Carbone,K., Chumakov,K. (2002). "Mumps virus (STRAIN JERYL-LYNN) live vaccine major component, complete genome". Virology.
- Complete genome of JL2 - Amexis,G., Rubin,S., Chizhikov,V., Pelloquin,F., Carbone,K., Chumakov,K. (2002). "Mumps virus (STRAIN JERYL-LYNN) live vaccine minor component JL2, complete genome". Virology.
[edit] See also
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