JDP2 (gene)

From Wikipedia, the free encyclopedia

Jun dimerization protein 2

Identifiers

JDP2; JUNDM2

External IDs

OMIM: 608657 MGI: 1932093 HomoloGene: 12787

Gene ontology
Molecular Function:	• transcription factor activity • sequence-specific DNA binding • protein dimerization activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

Refseq

NM_130469 (mRNA)
NP_569736 (protein)

NM_030887 (mRNA)
NP_112149 (protein)

Location

Chr 14: 74.96 - 75.01 Mb

Chr 12: 86.49 - 86.53 Mb

Pubmed search

[1]

[2]

Jun dimerization protein 2, also known as JDP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: JDP2 jun dimerization protein 2.

[edit] Further reading

Aronheim A, Zandi E, Hennemann H, et al. (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.". Mol. Cell. Biol. 17 (6): 3094–102. PMID 9154808.
Jin C, Ugai H, Song J, et al. (2001). "Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2.". FEBS Lett. 489 (1): 34–41. PMID 11231009.
Katz S, Heinrich R, Aronheim A (2001). "The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase.". FEBS Lett. 506 (3): 196–200. PMID 11602244.
Jin C, Li H, Murata T, et al. (2002). "JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.". Mol. Cell. Biol. 22 (13): 4815–26. PMID 12052888.
Wardell SE, Boonyaratanakornkit V, Adelman JS, et al. (2002). "Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.". Mol. Cell. Biol. 22 (15): 5451–66. PMID 12101239.
Katz S, Aronheim A (2003). "Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2.". Biochem. J. 368 (Pt 3): 939–45. doi:10.1042/BJ20021127. PMID 12225289.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kawaida R, Ohtsuka T, Okutsu J, et al. (2003). "Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL.". J. Exp. Med. 197 (8): 1029–35. doi:10.1084/jem.20021321. PMID 12707301.
Heinrich R, Livne E, Ben-Izhak O, Aronheim A (2004). "The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene.". J. Biol. Chem. 279 (7): 5708–15. doi:10.1074/jbc.M307608200. PMID 14627710.
Lerdrup M, Holmberg C, Dietrich N, et al. (2005). "Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis.". Biochim. Biophys. Acta 1745 (1): 29–37. doi:10.1016/j.bbamcr.2005.06.008. PMID 16026868.