ITPR1

From Wikipedia, the free encyclopedia

Inositol 1,4,5-triphosphate receptor, type 1

PDB rendering based on 1n4k.

Available structures: 1n4k, 1xzz

Identifiers

Symbol(s)

ITPR1; IP3R; IP3R1; Insp3r1

External IDs

OMIM: 147265 MGI: 96623 HomoloGene: 1673

Gene ontology
Molecular Function:	• ion channel activity • inositol 1,4,5-triphosphate-sensitive calcium-release channel activity • calcium channel activity • calcium ion binding • protein binding • inositol-1,4,5-triphosphate receptor activity • calcium ion transmembrane transporter activity
Cellular Component:	• endoplasmic reticulum • endoplasmic reticulum membrane • integral to plasma membrane • membrane
Biological Process:	• ion transport • calcium ion transport • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002222 (mRNA)
NP_002213 (protein)

NM_010585 (mRNA)
NP_034715 (protein)

Location

Chr 3: 4.51 - 4.86 Mb

Chr 6: 108.18 - 108.52 Mb

Pubmed search

[1]

[2]

Inositol 1,4,5-triphosphate receptor, type 1, also known as ITPR1, is a human gene.^[1]

[edit] See also

Inositol triphosphate

[edit] References

^ Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1.

[edit] Further reading

Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects.". Curr. HIV Res. 4 (1): 57–64. PMID 16454711.
Nucifora FC, Li SH, Danoff S, et al. (1996). "Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant.". Brain Res. Mol. Brain Res. 32 (2): 291–6. PMID 7500840.
Joseph SK, Lin C, Pierson S, et al. (1995). "Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.". J. Biol. Chem. 270 (40): 23310–6. PMID 7559486.
Harnick DJ, Jayaraman T, Ma Y, et al. (1995). "The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation.". J. Biol. Chem. 270 (6): 2833–40. PMID 7852357.
Yamada N, Makino Y, Clark RA, et al. (1994). "Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization.". Biochem. J. 302 ( Pt 3): 781–90. PMID 7945203.
Wojcikiewicz RJ, Furuichi T, Nakade S, et al. (1994). "Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation.". J. Biol. Chem. 269 (11): 7963–9. PMID 8132516.
Komalavilas P, Lincoln TM (1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase.". J. Biol. Chem. 269 (12): 8701–7. PMID 8132598.
Cameron AM, Steiner JP, Roskams AJ, et al. (1996). "Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux.". Cell 83 (3): 463–72. PMID 8521476.
Yan J, Khanna KK, Lavin MF (1996). "Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation.". Int. J. Radiat. Biol. 69 (5): 539–46. PMID 8648241.
Quinton TM, Dean WL (1996). "Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets.". Biochem. Biophys. Res. Commun. 224 (3): 740–6. doi:10.1006/bbrc.1996.1093. PMID 8713116.
Cameron AM, Nucifora FC, Fung ET, et al. (1997). "FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain.". J. Biol. Chem. 272 (44): 27582–8. PMID 9346894.
Deelman LE, Jonk LJ, Henning RH (1998). "The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor.". Gene 207 (2): 219–25. PMID 9511764.
Martin C, Chapman KE, Seckl JR, Ashley RH (1998). "Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.". Neuroscience 85 (1): 205–16. PMID 9607712.
Tu JC, Xiao B, Yuan JP, et al. (1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.". Neuron 21 (4): 717–26. PMID 9808459.
Kiselyov K, Xu X, Mozhayeva G, et al. (1998). "Functional interaction between InsP3 receptors and store-operated Htrp3 channels.". Nature 396 (6710): 478–82. doi:10.1038/24890. PMID 9853757.
Lin P, Yao Y, Hofmeister R, et al. (1999). "Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi.". J. Cell Biol. 145 (2): 279–89. PMID 10209024.
Schlossmann J, Ammendola A, Ashman K, et al. (2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta.". Nature 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538–42. PMID 10843712.
Tanimura A, Tojyo Y, Turner RJ (2000). "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.". J. Biol. Chem. 275 (35): 27488–93. doi:10.1074/jbc.M004495200. PMID 10874040.