ITPK1

From Wikipedia, the free encyclopedia

Inositol 1,3,4-triphosphate 5/6 kinase

PDB rendering based on 2odt.

Available structures: 2odt

Identifiers

Symbol(s)

ITPK1; ITRPK1

External IDs

OMIM: 601838 MGI: 2446159 HomoloGene: 8588

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • catalytic activity • ATP binding • kinase activity • transferase activity • hydrolase activity • isomerase activity • inositol tetrakisphosphate 1-kinase activity
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014216 (mRNA)
NP_055031 (protein)

NM_172584 (mRNA)
NP_766172 (protein)

Location

Chr 14: 92.47 - 92.65 Mb

Chr 12: 102.97 - 103.11 Mb

Pubmed search

[1]

[2]

Inositol 1,3,4-triphosphate 5/6 kinase, also known as ITPK1, is a human gene.^[1]

[edit] References

^ Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase.

[edit] Further reading

Wilson MP, Majerus PW (1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.". J. Biol. Chem. 271 (20): 11904–10. PMID 8662638.
Yang X, Shears SB (2001). "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.". Biochem. J. 351 Pt 3: 551–5. PMID 11042108.
Wilson MP, Sun Y, Cao L, Majerus PW (2001). "Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2.". J. Biol. Chem. 276 (44): 40998–1004. doi:10.1074/jbc.M106605200. PMID 11533064.
Ho MW, Yang X, Carew MA, et al. (2002). "Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.". Curr. Biol. 12 (6): 477–82. PMID 11909533.
Sun Y, Wilson MP, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.". J. Biol. Chem. 277 (48): 45759–64. doi:10.1074/jbc.M208709200. PMID 12324474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sun Y, Mochizuki Y, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis.". J. Biol. Chem. 278 (44): 43645–53. doi:10.1074/jbc.M300674200. PMID 12925536.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Qian X, Mitchell J, Wei SJ, et al. (2005). "The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase.". Biochem. J. 389 (Pt 2): 389–95. doi:10.1042/BJ20050297. PMID 15762844.
Miller GJ, Wilson MP, Majerus PW, Hurley JH (2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.". Mol. Cell 18 (2): 201–12. doi:10.1016/j.molcel.2005.03.016. PMID 15837423.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Chamberlain PP, Qian X, Stiles AR, et al. (2007). "Integration of inositol phosphate signaling pathways via human ITPK1.". J. Biol. Chem. 282 (38): 28117–25. doi:10.1074/jbc.M703121200. PMID 17616525.