ITM2B

From Wikipedia, the free encyclopedia

Integral membrane protein 2B

Identifiers

ITM2B; ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD

External IDs

OMIM: 603904 MGI: 1309517 HomoloGene: 7388

Gene ontology
Molecular Function:	• protein binding • ATP binding
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane
Biological Process:	• apoptosis • induction of apoptosis • nervous system development • sensory perception of sound

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021999 (mRNA)
NP_068839 (protein)

NM_008410 (mRNA)
NP_032436 (protein)

Location

Chr 13: 47.71 - 47.73 Mb

Chr 14: 72.1 - 72.12 Mb

Pubmed search

[1]

[2]

Integral membrane protein 2B, also known as ITM2B, is a human gene.^[1]

[edit] References

^ Entrez Gene: ITM2B integral membrane protein 2B.

[edit] Further reading

Rostagno A, Tomidokoro Y, Lashley T, et al. (2005). "Chromosome 13 dementias.". Cell. Mol. Life Sci. 62 (16): 1814–25. doi:10.1007/s00018-005-5092-5. PMID 15968464.
Ernst B, Dalby MA, Dalby A (1970). "Luria testing in demented patients.". Acta Neurol. Scand. 46: Suppl 43:97–8. PMID 5466275.
Pittois K, Deleersnijder W, Merregaert J (1998). "cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B.". Gene 217 (1-2): 141–9. PMID 9795190.
Vidal R, Frangione B, Rostagno A, et al. (1999). "A stop-codon mutation in the BRI gene associated with familial British dementia.". Nature 399 (6738): 776–81. doi:10.1038/21637. PMID 10391242.
Vidal R, Revesz T, Rostagno A, et al. (2000). "A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4920–5. doi:10.1073/pnas.080076097. PMID 10781099.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Fleischer A, Ayllón V, Dumoutier L, et al. (2002). "Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2.". Oncogene 21 (20): 3181–9. doi:10.1038/sj.onc.1205464. PMID 12082633.
Austen B, el-Agnaf O, Nagala S, et al. (2003). "Properties of neurotoxic peptides related to the BRI gene.". Biochem. Soc. Trans. 30 (4): 557–9. doi:10.1042/. PMID 12196136.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Akiyama H, Kondo H, Arai T, et al. (2004). "Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain.". Acta Neuropathol. 107 (1): 53–8. doi:10.1007/s00401-003-0783-1. PMID 14586629.
Choi SI, Vidal R, Frangione B, Levy E (2004). "Axonal transport of British and Danish amyloid peptides via secretory vesicles.". FASEB J. 18 (2): 373–5. doi:10.1096/fj.03-0730fje. PMID 14656991.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Matsuda S, Giliberto L, Matsuda Y, et al. (2005). "The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.". J. Biol. Chem. 280 (32): 28912–6. doi:10.1074/jbc.C500217200. PMID 15983050.
Fotinopoulou A, Tsachaki M, Vlavaki M, et al. (2005). "BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.". J. Biol. Chem. 280 (35): 30768–72. doi:10.1074/jbc.C500231200. PMID 16027166.
Ghiso J, Rostagno A, Tomidokoro Y, et al. (2006). "Genetic alterations of the BRI2 gene: familial British and Danish dementias.". Brain Pathol. 16 (1): 71–9. PMID 16612984.