ITK (gene)

From Wikipedia, the free encyclopedia

IL2-inducible T-cell kinase

1LUI

Available structures: 1lui, 1luk, 1lum, 1lun, 1sm2, 1snu, 1snx, 2etz, 2eu0

Identifiers

Symbol(s)

ITK; PSCTK2; EMT; LYK; MGC126257; MGC126258

External IDs

OMIM: 186973 MGI: 96621 HomoloGene: 4051

Gene ontology
Molecular Function:	• nucleotide binding • non-membrane spanning protein tyrosine kinase activity • ATP binding • zinc ion binding • kinase activity • transferase activity • metal ion binding
Biological Process:	• protein amino acid phosphorylation • cellular defense response • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005546 (mRNA)
NP_005537 (protein)

NM_010583 (mRNA)
NP_034713 (protein)

Location

Chr 5: 156.54 - 156.61 Mb

Chr 11: 46.17 - 46.23 Mb

Pubmed search

[1]

[2]

IL2-inducible T-cell kinase, also known as ITK, is a human gene.

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains SH2, SH3 and PH domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.^[1]

[edit] References

^ Entrez Gene: ITK IL2-inducible T-cell kinase.

[edit] Further reading

Kosaka Y, Felices M, Berg LJ (2006). "Itk and Th2 responses: action but no reaction.". Trends Immunol. 27 (10): 453–60. doi:10.1016/j.it.2006.08.006. PMID 16931156.
Langhans-Rajasekaran SA, Wan Y, Huang XY (1995). "Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8601–5. PMID 7567982.
Janis EM, Siliciano JD, Isaac DD, et al. (1995). "Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q.". Genomics 23 (1): 269–71. PMID 7829087.
Gibson S, Leung B, Squire JA, et al. (1993). "Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q.". Blood 82 (5): 1561–72. PMID 8364206.
Tanaka N, Asao H, Ohtani K, et al. (1993). "A novel human tyrosine kinase gene inducible in T cells by interleukin 2.". FEBS Lett. 324 (1): 1–5. PMID 8504851.
Rawlings DJ, Scharenberg AM, Park H, et al. (1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.". Science 271 (5250): 822–5. PMID 8629002.
Park H, Wahl MI, Afar DE, et al. (1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain.". Immunity 4 (5): 515–25. PMID 8630736.
Bunnell SC, Henry PA, Kolluri R, et al. (1996). "Identification of Itk/Tsk Src homology 3 domain ligands.". J. Biol. Chem. 271 (41): 25646–56. PMID 8810341.
Andreotti AH, Bunnell SC, Feng S, et al. (1997). "Regulatory intramolecular association in a tyrosine kinase of the Tec family.". Nature 385 (6611): 93–7. doi:10.1038/385093a0. PMID 8985255.
King PD, Sadra A, Teng JM, et al. (1997). "Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK.". J. Immunol. 158 (2): 580–90. PMID 8992971.
Heyeck SD, Wilcox HM, Bunnell SC, Berg LJ (1997). "Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.". J. Biol. Chem. 272 (40): 25401–8. PMID 9312162.
De Sepulveda P, Okkenhaug K, Rose JL, et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.". EMBO J. 18 (4): 904–15. doi:10.1093/emboj/18.4.904. PMID 10022833.
Kaukonen J, Savolainen ER, Palotie A (1999). "Human Emt tyrosine kinase is specifically expressed both in mature T-lymphocytes and T-cell associated hematopoietic malignancies.". Leuk. Lymphoma 32 (5-6): 513–22. PMID 10048424.
Shan X, Wange RL (1999). "Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment.". J. Biol. Chem. 274 (41): 29323–30. PMID 10506192.
Su YW, Zhang Y, Schweikert J, et al. (1999). "Interaction of SLP adaptors with the SH2 domain of Tec family kinases.". Eur. J. Immunol. 29 (11): 3702–11. PMID 10556826.
Perez-Villar JJ, Kanner SB (2000). "Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes.". J. Immunol. 163 (12): 6435–41. PMID 10586033.
Rajagopal K, Sommers CL, Decker DC, et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.". J. Exp. Med. 190 (11): 1657–68. PMID 10587356.
Bunnell SC, Diehn M, Yaffe MB, et al. (2000). "Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.". J. Biol. Chem. 275 (3): 2219–30. PMID 10636929.
Shan X, Czar MJ, Bunnell SC, et al. (2000). "Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.". Mol. Cell. Biol. 20 (18): 6945–57. PMID 10958690.
Hawkins J, Marcy A (2001). "Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity.". Protein Expr. Purif. 22 (2): 211–9. doi:10.1006/prep.2001.1447. PMID 11437596.