ITGB8

From Wikipedia, the free encyclopedia

Integrin, beta 8

Identifiers

External IDs

OMIM: 604160 MGI: 1338035 HomoloGene: 18567

Gene ontology
Molecular Function:	• receptor activity • protein binding
Cellular Component:	• integrin complex • membrane • integral to membrane
Biological Process:	• cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_002214 (mRNA)
NP_002205 (protein)

XM_484197 (mRNA)
XP_484197 (protein)

Location

Chr 7: 20.34 - 20.42 Mb

Chr 12: 119.61 - 119.65 Mb

Pubmed search

[1]

[2]

Integrin, beta 8, also known as ITGB8, is a human gene.^[1]

This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: ITGB8 integrin, beta 8.

[edit] Further reading

Moyle M, Napier MA, McLean JW (1991). "Cloning and expression of a divergent integrin subunit beta 8.". J. Biol. Chem. 266 (29): 19650–8. PMID 1918072.
Nishimura SL, Sheppard D, Pytela R (1994). "Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.". J. Biol. Chem. 269 (46): 28708–15. PMID 7525578.
Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM (1997). "Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo.". Am. J. Physiol. 273 (1 Pt 1): L256–63. PMID 9252563.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Cambier S, Mu DZ, O'Connell D, et al. (2001). "A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth.". Cancer Res. 60 (24): 7084–93. PMID 11156415.
Mu D, Cambier S, Fjellbirkeland L, et al. (2002). "The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1.". J. Cell Biol. 157 (3): 493–507. doi:10.1083/jcb.200109100. PMID 11970960.
Jarad G, Wang B, Khan S, et al. (2003). "Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis.". J. Biol. Chem. 277 (49): 47826–33. doi:10.1074/jbc.M204901200. PMID 12324452.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Fjellbirkeland L, Cambier S, Broaddus VC, et al. (2003). "Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue.". Am. J. Pathol. 163 (2): 533–42. PMID 12875973.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Yan W, Shao R (2006). "Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation.". J. Biol. Chem. 281 (28): 19700–8. doi:10.1074/jbc.M601856200. PMID 16702213.