ITGAE

From Wikipedia, the free encyclopedia

integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Identifiers
Symbol ITGAE
Alt. Symbols CD103, HUMINAE
Entrez 3682
HUGO 6147
OMIM 604682
RefSeq NM_002208
UniProt P38570
Other data
Locus Chr. 17 p13

Integrin, alpha E (ITGAE) also known as CD103 (Cluster of Differentiation 103) is an integrin.[1] CD103 is expressed on a subset of T cells, termed regulatory T cells (Tregs). Tregs are important for decreasing the immune response and appear to play a crucial role in the prevention of autoimmune diseases. Tregs are defined as CD4+CD25+Foxp3+ cells. Some CD4+FoxP3- cells also express CD103 and have been attributed regulatory activity.

[edit] See also

[edit] References

  1. ^ Kilshaw PJ, Higgins JM (2002). "Alpha E: no more rejection?". J. Exp. Med. 196 (7): 873–5. doi:10.1084/jem.20021404. PMID 12370249. 

[edit] External links