ITGAE
From Wikipedia, the free encyclopedia
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
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Identifiers | |
Symbol | ITGAE |
Alt. Symbols | CD103, HUMINAE |
Entrez | 3682 |
HUGO | 6147 |
OMIM | 604682 |
RefSeq | NM_002208 |
UniProt | P38570 |
Other data | |
Locus | Chr. 17 p13 |
Integrin, alpha E (ITGAE) also known as CD103 (Cluster of Differentiation 103) is an integrin.[1] CD103 is expressed on a subset of T cells, termed regulatory T cells (Tregs). Tregs are important for decreasing the immune response and appear to play a crucial role in the prevention of autoimmune diseases. Tregs are defined as CD4+CD25+Foxp3+ cells. Some CD4+FoxP3- cells also express CD103 and have been attributed regulatory activity.
[edit] See also
[edit] References
- ^ Kilshaw PJ, Higgins JM (2002). "Alpha E: no more rejection?". J. Exp. Med. 196 (7): 873–5. doi: . PMID 12370249.