ITGAD

From Wikipedia, the free encyclopedia

Integrin, alpha D

Identifiers

ITGAD; ADB2; CD11D; FLJ39841

External IDs

OMIM: 602453 MGI: 3578624 HomoloGene: 56919

Gene ontology
Molecular Function:	• magnesium ion binding • receptor activity • calcium ion binding • protein binding
Cellular Component:	• integrin complex • membrane • integral to membrane
Biological Process:	• immune response • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • cell-cell adhesion • activated T cell proliferation

Orthologs

Human

Mouse

n/a

Refseq

NM_005353 (mRNA)
NP_005344 (protein)

XM_986629 (mRNA)
XP_991723 (protein)

Location

Chr 16: 31.31 - 31.35 Mb

Chr 7: 127.97 - 128 Mb

Pubmed search

[1]

[2]

Integrin, alpha D, also known as ITGAD, is a human gene.^[1]

[edit] References

^ Entrez Gene: ITGAD integrin, alpha D.

[edit] Further reading

Wong DA, Davis EM, LeBeau M, Springer TA (1996). "Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit.". Gene 171 (2): 291-4. PMID 8666289.
Van der Vieren M, Le Trong H, Wood CL, et al. (1996). "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3.". Immunity 3 (6): 683-90. PMID 8777714.
Shelley CS, Da Silva N, Georgakis A, et al. (1998). "Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb.". Genomics 49 (2): 334-6. PMID 9598326.
Grayson MH, Van der Vieren M, Sterbinsky SA, et al. (1999). "alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1).". J. Exp. Med. 188 (11): 2187-91. PMID 9841932.
Van der Vieren M, Crowe DT, Hoekstra D, et al. (1999). "The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1.". J. Immunol. 163 (4): 1984-90. PMID 10438935.
Noti JD, Johnson AK, Dillon JD (2000). "Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3.". J. Biol. Chem. 275 (12): 8959-69. PMID 10722744.
Noti JD (2003). "Expression of the myeloid-specific leukocyte integrin gene CD11d during macrophage foam cell differentiation and exposure to lipoproteins.". Int. J. Mol. Med. 10 (6): 721-7. PMID 12429998.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Noti JD, Johnson AK, Dillon JD (2005). "The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells.". J. Biol. Chem. 280 (5): 3449-57. doi:10.1074/jbc.M412627200. PMID 15561714.