ITGA8

From Wikipedia, the free encyclopedia

Integrin, alpha 8

Identifiers

External IDs

OMIM: 604063 MGI: 109442 HomoloGene: 37396

Gene ontology
Molecular Function:	• receptor activity • calcium ion binding • protein binding
Cellular Component:	• integrin complex • membrane • integral to membrane
Biological Process:	• cell-matrix adhesion • integrin-mediated signaling pathway • memory • cell-cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003638 (mRNA)
NP_003629 (protein)

NM_001001309 (mRNA)
NP_001001309 (protein)

Location

Chr 10: 15.6 - 15.8 Mb

Chr 2: 12.02 - 12.22 Mb

Pubmed search

[1]

[2]

Integrin, alpha 8, also known as ITGA8, is a human gene.^[1]

[edit] References

^ Entrez Gene: ITGA8 integrin, alpha 8.

[edit] Further reading

Schnapp LM, Hatch N, Ramos DM, et al. (1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.". J. Biol. Chem. 270 (39): 23196–202. PMID 7559467.
Schnapp LM, Breuss JM, Ramos DM, et al. (1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells.". J. Cell. Sci. 108 ( Pt 2): 537–44. PMID 7768999.
Denda S, Müller U, Crossin KL, et al. (1998). "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C.". Biochemistry 37 (16): 5464–74. doi:10.1021/bi9727489. PMID 9548928.
Hartner A, Schöcklmann H, Pröls F, et al. (1999). "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis.". Kidney Int. 56 (4): 1468–80. doi:10.1046/j.1523-1755.1999.00662.x. PMID 10504498.
Littlewood Evans A, Müller U (2000). "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1.". Nat. Genet. 24 (4): 424–8. doi:10.1038/74286. PMID 10742111.
Brandenberger R, Schmidt A, Linton J, et al. (2001). "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney.". J. Cell Biol. 154 (2): 447–58. PMID 11470831.
Ljubimov AV, Saghizadeh M, Pytela R, et al. (2001). "Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas.". J. Histochem. Cytochem. 49 (11): 1341–50. PMID 11668187.
Valerius MT, Patterson LT, Feng Y, Potter SS (2002). "Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney.". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8090–5. doi:10.1073/pnas.122229199. PMID 12060755.
Lu M, Munger JS, Steadele M, et al. (2003). "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1.". J. Cell. Sci. 115 (Pt 23): 4641–8. PMID 12415008.
Bieritz B, Spessotto P, Colombatti A, et al. (2004). "Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation.". Kidney Int. 64 (1): 119–27. doi:10.1046/j.1523-1755.2003.00057.x. PMID 12787402.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Ekwa-Ekoka C, Diaz GA, Carlson C, et al. (2005). "Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8).". Matrix Biol. 23 (7): 487–96. doi:10.1016/j.matbio.2004.08.005. PMID 15579315.
Scherberich A, Tucker RP, Degen M, et al. (2005). "Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro.". Oncogene 24 (9): 1525–32. doi:10.1038/sj.onc.1208342. PMID 15592496.