ITGA7

From Wikipedia, the free encyclopedia

Integrin, alpha 7

Identifiers

ITGA7; FLJ25220

External IDs

OMIM: 600536 MGI: 102700 HomoloGene: 37592

Gene ontology
Molecular Function:	• receptor activity • calcium ion binding • protein binding
Cellular Component:	• integrin complex • membrane
Biological Process:	• cell adhesion • homophilic cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • muscle development • regulation of cell shape • blood vessel morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002206 (mRNA)
NP_002197 (protein)

NM_008398 (mRNA)
NP_032424 (protein)

Location

Chr 12: 54.36 - 54.39 Mb

Chr 10: 128.34 - 128.36 Mb

Pubmed search

[1]

[2]

Integrin, alpha 7, also known as ITGA7, is a human gene.^[1]

ITGA7 encodes integrin alpha chain 7. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 7 undergoes post-translational cleavage within the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. Alpha 7 beta 1 is the major integrin complex expressed in differentiated muscle cells. Splice variants of alpha 7 that differ in both the extracellular and cytoplasmic domains exist in the mouse; however, to date only a single human transcript type has been isolated: it contains extracellular and cytoplasmic domains corresponding to the mouse X2 and B variants, respectively. A unique extracellular splice variant has been identified in human, although it clearly represents a minor species and its biological significance is unclear.^[1]

[edit] References

^ ^a ^b Entrez Gene: ITGA7 integrin, alpha 7.

[edit] Further reading

Fornaro M, Languino LR (1998). "Alternatively spliced variants: a new view of the integrin cytoplasmic domain.". Matrix Biol. 16 (4): 185–93. PMID 9402008.
Song WK, Wang W, Foster RF, et al. (1992). "H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis.". J. Cell Biol. 117 (3): 643–57. PMID 1315319.
Kramer RH, Vu MP, Cheng YF, et al. (1992). "Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes.". Cell Regul. 2 (10): 805–17. PMID 1839357.
Wang W, Wu W, Desai T, et al. (1995). "Localization of the alpha 7 integrin gene (ITGA7) on human chromosome 12q13: clustering of integrin and Hox genes implies parallel evolution of these gene families.". Genomics 26 (3): 568–70. PMID 7607681.
Song WK, Wang W, Sato H, et al. (1994). "Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases.". J. Cell. Sci. 106 ( Pt 4): 1139–52. PMID 8126096.
Ziober BL, Vu MP, Waleh N, et al. (1994). "Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development.". J. Biol. Chem. 268 (35): 26773–83. PMID 8253814.
Martin PT, Kaufman SJ, Kramer RH, Sanes JR (1996). "Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction.". Dev. Biol. 174 (1): 125–39. doi:10.1006/dbio.1996.0057. PMID 8626012.
Ziober BL, Chen Y, Kramer RH (1997). "The laminin-binding activity of the alpha 7 integrin receptor is defined by developmentally regulated splicing in the extracellular domain.". Mol. Biol. Cell 8 (9): 1723–34. PMID 9307969.
Basora N, Vachon PH, Herring-Gillam FE, et al. (1997). "Relation between integrin alpha7Bbeta1 expression in human intestinal cells and enterocytic differentiation.". Gastroenterology 113 (5): 1510–21. PMID 9352853.
Mayer U, Saher G, Fässler R, et al. (1997). "Absence of integrin alpha 7 causes a novel form of muscular dystrophy.". Nat. Genet. 17 (3): 318–23. doi:10.1038/ng1197-318. PMID 9354797.
Leung E, Lim SP, Berg R, et al. (1998). "A novel extracellular domain variant of the human integrin alpha 7 subunit generated by alternative intron splicing.". Biochem. Biophys. Res. Commun. 243 (1): 317–25. doi:10.1006/bbrc.1998.8092. PMID 9473524.
Zolkiewska A, Thompson WC, Moss J (1998). "Interaction of integrin alpha 7 beta 1 in C2C12 myotubes and in solution with laminin.". Exp. Cell Res. 240 (1): 86–94. doi:10.1006/excr.1998.4002. PMID 9570924.
Hayashi YK, Chou FL, Engvall E, et al. (1998). "Mutations in the integrin alpha7 gene cause congenital myopathy.". Nat. Genet. 19 (1): 94–7. doi:10.1038/ng0598-94. PMID 9590299.
Vignier N, Moghadaszadeh B, Gary F, et al. (1999). "Structure, genetic localization, and identification of the cardiac and skeletal muscle transcripts of the human integrin alpha7 gene (ITGA7).". Biochem. Biophys. Res. Commun. 260 (2): 357–64. doi:10.1006/bbrc.1999.0916. PMID 10403775.
Tachibana I, Hemler ME (1999). "Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance.". J. Cell Biol. 146 (4): 893–904. PMID 10459022.
Schöber S, Mielenz D, Echtermeyer F, et al. (2000). "The role of extracellular and cytoplasmic splice domains of alpha7-integrin in cell adhesion and migration on laminins.". Exp. Cell Res. 255 (2): 303–13. doi:10.1006/excr.2000.4806. PMID 10694445.
Wixler V, Geerts D, Laplantine E, et al. (2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.
Burkin DJ, Kim JE, Gu M, Kaufman SJ (2000). "Laminin and alpha7beta1 integrin regulate agrin-induced clustering of acetylcholine receptors.". J. Cell. Sci. 113 ( Pt 16): 2877–86. PMID 10910772.
Vizirianakis IS, Yao CC, Chen Y, et al. (2001). "Transfection of MCF-7 carcinoma cells with human integrin alpha7 cDNA promotes adhesion to laminin.". Arch. Biochem. Biophys. 385 (1): 108–16. doi:10.1006/abbi.2000.2134. PMID 11361006.