ITGA6
From Wikipedia, the free encyclopedia
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Integrin, alpha 6
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| Identifiers | ||||||||||||||
| Symbol(s) | ITGA6; CD49f; ITGA6B; VLA-6 | |||||||||||||
| External IDs | OMIM: 147556 MGI: 96605 HomoloGene: 20091 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3655 | 16403 | ||||||||||||
| Ensembl | ENSG00000091409 | ENSMUSG00000027111 | ||||||||||||
| Uniprot | P23229 | Q3TWK2 | ||||||||||||
| Refseq | NM_000210 (mRNA) NP_000201 (protein) |
NM_008397 (mRNA) NP_032423 (protein) |
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| Location | Chr 2: 173 - 173.08 Mb | Chr 2: 71.59 - 71.66 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Integrin, alpha 6, also known as ITGA6, is a human gene.
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Lipscomb EA, Mercurio AM (2006). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression.". Cancer Metastasis Rev. 24 (3): 413–23. doi:. PMID 16258729.
[edit] External links
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