ITGA2B

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Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
PDB rendering based on 1txv.
Available structures: 1txv, 1ty3, 1ty5, 1ty6, 1ty7, 1tye
Identifiers
Symbol(s) ITGA2B; GTA; CD41; CD41B; GP2B; GPIIb; HPA3
External IDs OMIM: 607759 MGI: 96601 HomoloGene: 37304
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3674 16399
Ensembl ENSG00000005961 ENSMUSG00000034664
Uniprot P08514 Q3U3R7
Refseq NM_000419 (mRNA)
NP_000410 (protein)		 NM_010575 (mRNA)
NP_034705 (protein)
Location Chr 17: 39.81 - 39.82 Mb Chr 11: 102.27 - 102.29 Mb
Pubmed search [1] [2]

Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), also known as ITGA2B, is a human gene.

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[1]

Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41).

[edit] Further reading

  • Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.". Thromb. Haemost. 72 (4): 492–502. PMID 7878622. 
  • Naik UP, Parise LV (1997). "Structure and function of platelet alpha IIb beta 3.". Curr. Opin. Hematol. 4 (5): 317–22. PMID 9288464. 
  • Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390–6. PMID 9789327. 
  • Lincoff AM (1998). "Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization.". Am. J. Cardiol. 82 (8B): 36P–42P. PMID 9809890. 
  • Bennett JS (2001). "Platelet-fibrinogen interactions.". Ann. N. Y. Acad. Sci. 936: 340–54. PMID 11460491. 
  • Plow EF, Cierniewski CS, Xiao Z, et al. (2002). "AlphaIIbbeta3 and its antagonism at the new millennium.". Thromb. Haemost. 86 (1): 34–40. PMID 11487023. 
  • Quinn MJ, Byzova TV, Qin J, et al. (2004). "Integrin alphaIIbbeta3 and its antagonism.". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945–52. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342. 
  • Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis.". Curr. Pharm. Des. 10 (14): 1567–76. PMID 15134555. 
  • Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets.". J. Thromb. Haemost. 3 (8): 1752–62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042. 
  • Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3.". J. Clin. Invest. 115 (12): 3363–9. doi:10.1172/JCI26989. PMID 16322781. 
  • Ma YQ, Qin J, Plow EF (2007). "Platelet integrin alpha(IIb)beta(3): activation mechanisms.". J. Thromb. Haemost. 5 (7): 1345–52. doi:10.1111/j.1538-7836.2007.02537.x. PMID 17635696. 

[edit] External links

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v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350