ITGA11

From Wikipedia, the free encyclopedia

Integrin, alpha 11

Identifiers

ITGA11; HsT18964

External IDs

OMIM: 604789 MGI: 2442114 HomoloGene: 8151

Gene ontology
Molecular Function:	• magnesium ion binding • receptor activity • calcium ion binding • collagen binding
Cellular Component:	• integrin complex • membrane • integral to membrane
Biological Process:	• substrate-bound cell migration • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • muscle development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001004439 (mRNA)
NP_001004439 (protein)

NM_176922 (mRNA)
NP_795896 (protein)

Location

Chr 15: 66.38 - 66.51 Mb

Chr 9: 62.48 - 62.58 Mb

Pubmed search

[1]

[2]

Integrin, alpha 11, also known as ITGA11, is a human gene.^[1]

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: ITGA11 integrin, alpha 11.

[edit] Further reading

Zhu CQ, Popova SN, Brown ER, et al. (2007). "Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells.". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11754–9. doi:10.1073/pnas.0703040104. PMID 17600088.
Leomil Coelho LF, Mota BE, Sales PC, et al. (2006). "Integrin alpha 11 is a novel type I interferon stimulated gene.". Cytokine 33 (6): 352–61. doi:10.1016/j.cyto.2006.03.007. PMID 16697656.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhang WM, Kapyla J, Puranen JS, et al. (2003). "alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens.". J. Biol. Chem. 278 (9): 7270–7. doi:10.1074/jbc.M210313200. PMID 12496264.
Zhang WM, Popova SN, Bergman C, et al. (2003). "Analysis of the human integrin alpha11 gene (ITGA11) and its promoter.". Matrix Biol. 21 (6): 513–23. PMID 12392762.
Tiger CF, Fougerousse F, Grundström G, et al. (2001). "alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells.". Dev. Biol. 237 (1): 116–29. doi:10.1006/dbio.2001.0363. PMID 11518510.
Lehnert K, Ni J, Leung E, et al. (1999). "Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11).". Genomics 60 (2): 179–87. doi:10.1006/geno.1999.5909. PMID 10486209.
Velling T, Kusche-Gullberg M, Sejersen T, Gullberg D (1999). "cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues.". J. Biol. Chem. 274 (36): 25735–42. PMID 10464311.