Isoquinoline 1-oxidoreductase

From Wikipedia, the free encyclopedia

In enzymology, an isoquinoline 1-oxidoreductase (EC 1.3.99.16) is an enzyme that catalyzes the chemical reaction

isoquinoline + acceptor + H₂O isoquinolin-1(2H)-one + reduced acceptor

The 3 substrates of this enzyme are isoquinoline, acceptor, and H₂O, whereas its two products are isoquinolin-1(2H)-one and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is isoquinoline:acceptor 1-oxidoreductase (hydroxylating).

[edit] References

• IUBMB entry for 1.3.99.16
• BRENDA references for 1.3.99.16 (Recommended.)
• PubMed references for 1.3.99.16
• PubMed Central references for 1.3.99.16
• Google Scholar references for 1.3.99.16
• Lehmann M, Tshisuaka B, Fetzner S, Roger P, Lingens F (1994). "Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase". J. Biol. Chem. 269: 11254–60. PMID 8157655. 
• Lehmann M, Tshisuaka B, Fetzner S, Lingens F (1995). "Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases". J. Biol. Chem. 270: 14420–9. doi:10.1074/jbc.270.24.14420. PMID 7782304. 

[edit] External links

The CAS registry number for this enzyme class is 155948-73-5.

• IUBMB entry for 1.3.99.16

• KEGG entry for 1.3.99.16

• BRENDA entry for 1.3.99.16

• NiceZyme view of 1.3.99.16

• EC2PDB: PDB structures for 1.3.99.16

• PRIAM entry for 1.3.99.16

• PUMA2 entry for 1.3.99.16

• IntEnz: Integrated Enzyme entry for 1.3.99.16

• MetaCyc entry for 1.3.99.16

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047121: isoquinoline 1-oxidoreductase

• AMIGO entry for GO code 0047121: isoquinoline 1-oxidoreductase