Isopentenyl-diphosphate Delta-isomerase

From Wikipedia, the free encyclopedia

In enzymology, an isopentenyl-diphosphate Delta-isomerase (EC 5.3.3.2) is an enzyme that catalyzes the chemical reaction

isopentenyl diphosphate dimethylallyl diphosphate

Hence, this enzyme has one substrate, isopentenyl diphosphate, and one product, dimethylallyl diphosphate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is isopentenyl-diphosphate Delta3-Delta2-isomerase. Other names in common use include isopentenylpyrophosphate Delta-isomerase, methylbutenylpyrophosphate isomerase, and isopentenylpyrophosphate isomerase. This enzyme participates in biosynthesis of steroids and terpenoid biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 25 structures have been solved for this class of enzymes, with PDB accession codes 1HX3, 1HZT, 1I9A, 1NFS, 1NFZ, 1OW2, 1P0K, 1P0N, 1PPV, 1PPW, 1PVF, 1Q54, 1R67, 1VCF, 1VCG, 1X83, 1X84, 2B2K, 2DHO, 2G73, 2G74, 2I6K, 2ICJ, 2ICK, and 2PNY.

[edit] References

• IUBMB entry for 5.3.3.2
• BRENDA references for 5.3.3.2 (Recommended.)
• PubMed references for 5.3.3.2
• PubMed Central references for 5.3.3.2
• Google Scholar references for 5.3.3.2
• Kaneda K, Kuzuyama T, Takagi M, Hayakawa Y, Seto H (2001). "An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190". Proc. Natl. Acad. Sci. U. S. A. 98: 932–7. doi:10.1073/pnas.020472198. PMID 11158573. 
• Bishop JM (1983). "Cellular oncogenes and retroviruses". Annu. Rev. Biochem. 52: 301–54. doi:10.1146/annurev.bi.52.070183.001505. PMID 6351725. 
• AGRANOFF BW, EGGERER H, HENNING U, LYNEN F (1960). "Biosynthesis of terpenes. VII. Isopentenyl pyrophosphate isomerase". J. Biol. Chem. 235: 326–32. PMID 13792054. 

[edit] External links

The CAS registry number for this enzyme class is 9033-27-6.

• IUBMB entry for 5.3.3.2

• KEGG entry for 5.3.3.2

• BRENDA entry for 5.3.3.2

• NiceZyme view of 5.3.3.2

• EC2PDB: PDB structures for 5.3.3.2

• PRIAM entry for 5.3.3.2

• PUMA2 entry for 5.3.3.2

• IntEnz: Integrated Enzyme entry for 5.3.3.2

• MetaCyc entry for 5.3.3.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004452: isopentenyl-diphosphate delta-isomerase

• AMIGO entry for GO code 0004452: isopentenyl-diphosphate delta-isomerase