Isohexenylglutaconyl-CoA hydratase

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In enzymology, an isohexenylglutaconyl-CoA hydratase (EC 4.2.1.57) is an enzyme that catalyzes the chemical reaction

3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H₂O

Hence, this enzyme has one substrate, 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA, and two products, 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]. Other names in common use include 3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase, isohexenylglutaconyl coenzyme A hydratase, beta-isohexenylglutaconyl-CoA-hydratase, and 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase.

[edit] References

• IUBMB entry for 4.2.1.57
• BRENDA references for 4.2.1.57 (Recommended.)
• PubMed references for 4.2.1.57
• PubMed Central references for 4.2.1.57
• Google Scholar references for 4.2.1.57
• SEUBERT W, FASS E (1964). "[STUDIES ON THE BACTERIAL DEGRADATION OF ISOPRENOIDS. IV. THE PURIFICATION AND PROPERTIES OF BETA-ISOHEXENYLGLUTACONYL-COA-HYDRATASE AND BETA-HYDROXY-BETA-ISOHEXENYLGLUTARYL-COA-LYASE.]". Biochem. Z. 341: 23–34. PMID 14339651. 

[edit] External links

The CAS registry number for this enzyme class is 37290-84-9.

• IUBMB entry for 4.2.1.57

• KEGG entry for 4.2.1.57

• BRENDA entry for 4.2.1.57

• NiceZyme view of 4.2.1.57

• EC2PDB: PDB structures for 4.2.1.57

• PRIAM entry for 4.2.1.57

• PUMA2 entry for 4.2.1.57

• IntEnz: Integrated Enzyme entry for 4.2.1.57

• MetaCyc entry for 4.2.1.57

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050005: isohexenylglutaconyl-CoA hydratase

• AMIGO entry for GO code 0050005: isohexenylglutaconyl-CoA hydratase