Isochorismate synthase

From Wikipedia, the free encyclopedia

In enzymology, an isochorismate synthase (EC 5.4.4.2) is an enzyme that catalyzes the chemical reaction

chorismate $\rightleftharpoons$ isochorismate

Hence, this enzyme has one substrate, chorismate, and one product, isochorismate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring hydroxy groups. The systematic name of this enzyme class is isochorismate hydroxymutase. This enzyme participates in 2 metabolic pathways: ubiquinone biosynthesis and biosynthesis of siderophore group.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2EUA.

[edit] References

IUBMB entry for 5.4.4.2
BRENDA references for 5.4.4.2 (Recommended.)
PubMed references for 5.4.4.2
PubMed Central references for 5.4.4.2
Google Scholar references for 5.4.4.2
Young IG, Gibson F (1969). "Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli". Biochim. Biophys. Acta. 177: 401–11. PMID 4306838.
van Tegelen LJ, Moreno PR, Croes AF, Verpoorte R, Wullems GJ (1999). "Purification and cDNA cloning of isochorismate synthase from elicited cell cultures of Catharanthus roseus". Plant. Physiol. 119: 705–12. doi:10.1104/pp.119.2.705. PMID 9952467.
Dahm C, Muller R, Schulte G, Schmidt K, Leistner E (1998). "The role of isochorismate hydroxymutase genes entC and menF in enterobactin and menaquinone biosynthesis in Escherichia coli". Biochim. Biophys. Acta. 1425: 377–86. PMID 9795253.