Isochorismatase

From Wikipedia, the free encyclopedia

In enzymology, an isochorismatase (EC 3.3.2.1) is an enzyme that catalyzes the chemical reaction

isochorismate + H₂O 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Thus, the two substrates of this enzyme are isochorismate and H₂O, whereas its two products are 2,3-dihydroxy-2,3-dihydrobenzoate and pyruvate.

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is isochorismate pyruvate-hydrolase. Other names in common use include 2,3-dihydro-2,3-dihydroxybenzoate synthase, 2,3-dihydroxy-2,3-dihydrobenzoate synthase, and 2,3-dihydroxy-2,3-dihydrobenzoic synthase. This enzyme participates in the biosynthesis of siderophore group (nonribosomal).

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1NF8, 1NF9, and 2FQ1.

[edit] References

• IUBMB entry for 3.3.2.1
• BRENDA references for 3.3.2.1 (Recommended.)
• PubMed references for 3.3.2.1
• PubMed Central references for 3.3.2.1
• Google Scholar references for 3.3.2.1
• Young IG, Gibson F (1969). "Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli". Biochim. Biophys. Acta. 177: 401–11. PMID 4306838. 

[edit] External links

The CAS registry number for this enzyme class is 37288-64-5.

• IUBMB entry for 3.3.2.1

• KEGG entry for 3.3.2.1

• BRENDA entry for 3.3.2.1

• NiceZyme view of 3.3.2.1

• EC2PDB: PDB structures for 3.3.2.1

• PRIAM entry for 3.3.2.1

• PUMA2 entry for 3.3.2.1

• IntEnz: Integrated Enzyme entry for 3.3.2.1

• MetaCyc entry for 3.3.2.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008908: isochorismatase

• AMIGO entry for GO code 0008908: isochorismatase