ISCU

From Wikipedia, the free encyclopedia

Iron-sulfur cluster scaffold homolog (E. coli)

PDB rendering based on 1wfz.

Available structures: 1wfz

Identifiers

Symbol(s)

ISCU; 2310020H20Rik; ISU2; MGC74517; NIFU; NIFUN; hnifU

External IDs

MGI: 1913633 HomoloGene: 6991

Gene ontology
Molecular Function:	• iron ion binding • metal ion binding
Cellular Component:	• nucleus • cytoplasm • mitochondrion
Biological Process:	• nitrogen fixation • iron-sulfur cluster assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014301 (mRNA)
NP_055116 (protein)

NM_025526 (mRNA)
NP_079802 (protein)

Location

Chr 12: 107.48 - 107.49 Mb

Chr 5: 114.03 - 114.04 Mb

Pubmed search

[1]

[2]

Iron-sulfur cluster scaffold homolog (E. coli), also known as ISCU, is a human gene.^[1]

[edit] References

^ Entrez Gene: ISCU iron-sulfur cluster scaffold homolog (E. coli).

[edit] Further reading

Mochel F, Knight MA, Tong WH, et al. (2008). "Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.". Am. J. Hum. Genet. 82 (3): 652-60. doi:10.1016/j.ajhg.2007.12.012. PMID 18304497.
Li K, Tong WH, Hughes RM, Rouault TA (2006). "Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly.". J. Biol. Chem. 281 (18): 12344-51. doi:10.1074/jbc.M600582200. PMID 16527810.
Tong WH, Rouault TA (2006). "Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis.". Cell Metab. 3 (3): 199-210. doi:10.1016/j.cmet.2006.02.003. PMID 16517407.
Acquaviva F, De Biase I, Nezi L, et al. (2005). "Extra-mitochondrial localisation of frataxin and its association with IscU1 during enterocyte-like differentiation of the human colon adenocarcinoma cell line Caco-2.". J. Cell. Sci. 118 (Pt 17): 3917-24. doi:10.1242/jcs.02516. PMID 16091420.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785-95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Tong WH, Rouault T (2000). "Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells.". EMBO J. 19 (21): 5692-700. doi:10.1093/emboj/19.21.5692. PMID 11060020.
Hwang DM, Dempsey A, Tan KT, Liew CC (1997). "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.". J. Mol. Evol. 43 (5): 536-40. PMID 8875867.