IRS4

From Wikipedia, the free encyclopedia

Insulin receptor substrate 4

Identifiers

IRS4; IRS-4; PY160

External IDs

OMIM: 603510 MGI: 1338009 HomoloGene: 2673

Gene ontology
Molecular Function:	• receptor activity • SH3/SH2 adaptor activity • insulin receptor binding
Cellular Component:	• plasma membrane
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003604 (mRNA)
NP_003595 (protein)

XM_980033 (mRNA)
XP_985127 (protein)

Location

Chr X: 107.86 - 107.87 Mb

n/a

Pubmed search

[1]

[2]

Insulin receptor substrate 4, also known as IRS4, is a human gene.^[1]

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation..^[1]

[edit] References

^ ^a ^b Entrez Gene: IRS4 insulin receptor substrate 4.

[edit] Further reading

White MF (1999). "The IRS-signalling system: a network of docking proteins that mediate insulin action.". Mol. Cell. Biochem. 182 (1-2): 3-11. PMID 9609109.
Lavan BE, Fantin VR, Chang ET, et al. (1997). "A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family.". J. Biol. Chem. 272 (34): 21403-7. PMID 9261155.
Fantin VR, Sparling JD, Slot JW, et al. (1998). "Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells.". J. Biol. Chem. 273 (17): 10726-32. PMID 9553137.
Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.". J. Biol. Chem. 273 (24): 14780-7. PMID 9614078.
Uchida T, Myers MG, White MF (2000). "IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.". Mol. Cell. Biol. 20 (1): 126-38. PMID 10594015.
Karas M, Koval AP, Zick Y, LeRoith D (2001). "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II.". Endocrinology 142 (5): 1835-40. PMID 11316748.
Sano H, Liu SC, Lane WS, et al. (2002). "Insulin receptor substrate 4 associates with the protein IRAS.". J. Biol. Chem. 277 (22): 19439-47. doi:10.1074/jbc.M111838200. PMID 11912194.
Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.". Mol. Cell. Biol. 22 (13): 4567-78. PMID 12052866.
Schreyer S, Ledwig D, Rakatzi I, et al. (2003). "Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.". Endocrinology 144 (4): 1211-8. PMID 12639902.
Escribano O, Fernández-Moreno MD, Zueco JA, et al. (2003). "Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver.". Hepatology 37 (6): 1461-9. doi:10.1053/jhep.2003.50245. PMID 12774026.
Yen HW, Jakimiuk AJ, Munir I, Magoffin DA (2005). "Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries.". Mol. Hum. Reprod. 10 (7): 473-9. doi:10.1093/molehr/gah066. PMID 15155816.
Hinsby AM, Olsen JV, Mann M (2004). "Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.". J. Biol. Chem. 279 (45): 46438-47. doi:10.1074/jbc.M404537200. PMID 15316024.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Mihindukulasuriya KA, Zhou G, Qin J, Tan TH (2004). "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.". J. Biol. Chem. 279 (45): 46588-94. doi:10.1074/jbc.M408067200. PMID 15331607.
Qiu H, Zappacosta F, Su W, et al. (2005). "Interaction between Brk kinase and insulin receptor substrate-4.". Oncogene 24 (36): 5656-64. doi:10.1038/sj.onc.1208721. PMID 15870689.
Cuevas EP, Escribano O, Chiloeches A, et al. (2007). "Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation.". J. Hepatol. 46 (6): 1089-98. doi:10.1016/j.jhep.2007.01.031. PMID 17408801.