IRAK2

From Wikipedia, the free encyclopedia

Interleukin-1 receptor-associated kinase 2

Identifiers

IRAK2; IRAK-2; MGC150550

External IDs

OMIM: 603304 MGI: 2429603 HomoloGene: 1207

Gene ontology
Molecular Function:	• protein kinase activity • NF-kappaB-inducing kinase activity • ATP binding • identical protein binding
Cellular Component:	• cell surface
Biological Process:	• protein amino acid phosphorylation • inflammatory response • signal transduction • I-kappaB kinase/NF-kappaB cascade • lipopolysaccharide-mediated signaling pathway • negative regulation of transcription factor activity • activation of NF-kappaB transcription factor

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001570 (mRNA)
NP_001561 (protein)

XM_974569 (mRNA)
XP_979663 (protein)

Location

Chr 3: 10.18 - 10.26 Mb

n/a

Pubmed search

[1]

[2]

Interleukin-1 receptor-associated kinase 2, also known as IRAK2, is a human gene.^[1]

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.^[1]

[edit] References

^ ^a ^b Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2.

[edit] Further reading

Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction.". Cytokine Growth Factor Rev. 9 (3-4): 221–37. PMID 9918122.
Muzio M, Ni J, Feng P, Dixit VM (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.". Science 278 (5343): 1612–5. PMID 9374458.
Maschera B, Ray K, Burns K, Volpe F (1999). "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB.". Biochem. J. 339 ( Pt 2): 227–31. PMID 10191251.
Wesche H, Gao X, Li X, et al. (1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.". J. Biol. Chem. 274 (27): 19403–10. PMID 10383454.
Fitzgerald KA, Palsson-McDermott EM, Bowie AG, et al. (2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.". Nature 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529.
McDermott EP, O'Neill LA (2002). "Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1.". J. Biol. Chem. 277 (10): 7808–15. doi:10.1074/jbc.M108133200. PMID 11744690.
Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kuzmin I, Geil L, Gibson L, et al. (2005). "Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter.". J. Mol. Biol. 346 (2): 411–22. doi:10.1016/j.jmb.2004.11.066. PMID 15670593.
Keating SE, Maloney GM, Moran EM, Bowie AG (2008). "IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination.". J. Biol. Chem. 282 (46): 33435–43. doi:10.1074/jbc.M705266200. PMID 17878161.