IQSEC1

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IQ motif and Sec7 domain 1
Identifiers
Symbol(s) IQSEC1; KIAA0763
External IDs OMIM: 610166 HomoloGene: 82429
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9922 n/a
Ensembl ENSG00000144711 n/a
Uniprot Q6DN90 n/a
Refseq NM_014869 (mRNA)
NP_055684 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 3: 12.91 - 12.98 Mb n/a
Pubmed search [1] n/a

IQ motif and Sec7 domain 1 (IQSEC1) is a human gene.[1] The protein encoded by this gene is also known as ARF-GEP100 (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa).[2]

Contents

[edit] Function

The ARF-GEP100 protein is involved in signal transduction. It is a guanine nucleotide exchange factor that promotes binding of GTP to ADP ribosylation factor protein ARF6 and to a lesser extent ARF1 and ARF5.[2] This activates the ADP-ribosylation activity of the target protein and cause it to modify its substrates. ARF-GEP100, through activation of ARF6, is therefore involved in the control of processes such as endocytosis of plasma membrane proteins, E-cadherin recycling and actin cytoskeleton remodeling.[3] ARF-GEP100 appears particularly important in regulating cell adhesion, with reductions in the level of this protein causing enhanced spreading and attachment of cells.[4]

[edit] References

  1. ^ Entrez Gene: IQSEC1 IQ motif and Sec7 domain 1.
  2. ^ a b Someya A, Sata M, Takeda K, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (2001). "ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2413–8. doi:10.1073/pnas.051634798. PMID 11226253. 
  3. ^ Hiroi T, Someya A, Thompson W, Moss J, Vaughan M (2006). "GEP100/BRAG2: activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin". Proc. Natl. Acad. Sci. U.S.A. 103 (28): 10672–7. doi:10.1073/pnas.0604091103. PMID 16807291. 
  4. ^ Dunphy JL, Moravec R, Ly K, Lasell TK, Melancon P, Casanova JE (2006). "The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins". Curr. Biol. 16 (3): 315–20. doi:10.1016/j.cub.2005.12.032. PMID 16461286. 

[edit] Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452. 
  • Someya A, Sata M, Takeda K, et al. (2001). "ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6.". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2413–8. doi:10.1073/pnas.051634798. PMID 11226253. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 

[edit] External links

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