IQGAP1

From Wikipedia, the free encyclopedia

IQ motif containing GTPase activating protein 1

PDB rendering based on 1x0h.

Available structures: 1x0h

Identifiers

Symbol(s)

IQGAP1; HUMORFA01; KIAA0051; SAR1; p195

External IDs

OMIM: 603379 MGI: 1352757 HomoloGene: 74514

Gene ontology
Molecular Function:	• GTPase inhibitor activity • Ras GTPase activator activity • calmodulin binding
Cellular Component:	• intracellular • cytoplasm • actin filament • membrane
Biological Process:	• signal transduction • negative regulation of Ras protein signal transduction • regulation of small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003870 (mRNA)
NP_003861 (protein)

NM_016721 (mRNA)
NP_057930 (protein)

Location

Chr 15: 88.73 - 88.85 Mb

Chr 7: 80.59 - 80.68 Mb

Pubmed search

[1]

[2]

IQ motif containing GTPase activating protein 1, also known as IQGAP1, is a human gene.^[1]

This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.^[1]

[edit] References

^ ^a ^b Entrez Gene: IQGAP1 IQ motif containing GTPase activating protein 1.

[edit] Further reading

Tirnauer JS (2005). "A new cytoskeletal connection for APC: linked to actin through IQGAP.". Dev. Cell 7 (6): 778–80. doi:10.1016/j.devcel.2004.11.012. PMID 15572120.
Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. PMID 7584044.
Weissbach L, Settleman J, Kalady MF, et al. (1994). "Identification of a human rasGAP-related protein containing calmodulin-binding motifs.". J. Biol. Chem. 269 (32): 20517–21. PMID 8051149.
Hart MJ, Callow MG, Souza B, Polakis P (1996). "IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs.". EMBO J. 15 (12): 2997–3005. PMID 8670801.
McCallum SJ, Wu WJ, Cerione RA (1996). "Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2.". J. Biol. Chem. 271 (36): 21732–7. PMID 8702968.
Brill S, Li S, Lyman CW, et al. (1996). "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases.". Mol. Cell. Biol. 16 (9): 4869–78. PMID 8756646.
Kuroda S, Fukata M, Kobayashi K, et al. (1996). "Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1.". J. Biol. Chem. 271 (38): 23363–7. PMID 8798539.
Joyal JL, Annan RS, Ho YD, et al. (1997). "Calmodulin modulates the interaction between IQGAP1 and Cdc42. Identification of IQGAP1 by nanoelectrospray tandem mass spectrometry.". J. Biol. Chem. 272 (24): 15419–25. PMID 9182573.
Bashour AM, Fullerton AT, Hart MJ, Bloom GS (1997). "IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments.". J. Cell Biol. 137 (7): 1555–66. PMID 9199170.
McCallum SJ, Erickson JW, Cerione RA (1998). "Characterization of the association of the actin-binding protein, IQGAP, and activated Cdc42 with Golgi membranes.". J. Biol. Chem. 273 (35): 22537–44. PMID 9712880.
Li Z, Kim SH, Higgins JM, et al. (2000). "IQGAP1 and calmodulin modulate E-cadherin function.". J. Biol. Chem. 274 (53): 37885–92. PMID 10608854.
Berryman M, Bretscher A (2000). "Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli.". Mol. Biol. Cell 11 (5): 1509–21. PMID 10793131.
Sugimoto N, Imoto I, Fukuda Y, et al. (2001). "IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A.". J. Hum. Genet. 46 (1): 21–5. PMID 11289714.
Briggs MW, Li Z, Sacks DB (2002). "IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin.". J. Biol. Chem. 277 (9): 7453–65. doi:10.1074/jbc.M104315200. PMID 11734550.
Nabeshima K, Shimao Y, Inoue T, Koono M (2002). "Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts.". Cancer Lett. 176 (1): 101–9. PMID 11790459.
Mateer SC, McDaniel AE, Nicolas V, et al. (2002). "The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin.". J. Biol. Chem. 277 (14): 12324–33. doi:10.1074/jbc.M109535200. PMID 11809768.
Swart-Mataraza JM, Li Z, Sacks DB (2002). "IQGAP1 is a component of Cdc42 signaling to the cytoskeleton.". J. Biol. Chem. 277 (27): 24753–63. doi:10.1074/jbc.M111165200. PMID 11948177.
Fukata M, Watanabe T, Noritake J, et al. (2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170.". Cell 109 (7): 873–85. PMID 12110184.
Mbele GO, Deloulme JC, Gentil BJ, et al. (2003). "The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes.". J. Biol. Chem. 277 (51): 49998–50007. doi:10.1074/jbc.M205363200. PMID 12377780.
Li Z, Sacks DB (2003). "Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1.". J. Biol. Chem. 278 (6): 4347–52. doi:10.1074/jbc.M208579200. PMID 12446675.