IPO7

From Wikipedia, the free encyclopedia

Importin 7

Identifiers

IPO7; FLJ14581; MGC138673; RANBP7

External IDs

OMIM: 605586 MGI: 2152414 HomoloGene: 4659

Gene ontology
Molecular Function:	• small GTPase regulator activity • protein binding • Ran GTPase binding • protein transporter activity
Cellular Component:	• soluble fraction • nucleus • nuclear pore • cytoplasm
Biological Process:	• protein import into nucleus, docking • intracellular protein transport • signal transduction

Orthologs

Human

Mouse

Refseq

NM_006391 (mRNA)
NP_006382 (protein)

NM_181517 (mRNA)
NP_852658 (protein)

Location

Chr 11: 9.36 - 9.42 Mb

Chr 7: 109.81 - 109.85 Mb

Pubmed search

[1]

[2]

Importin 7, also known as IPO7, is a human gene.^[1]

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: IPO7 importin 7.

[edit] Further reading

Görlich D, Dabrowski M, Bischoff FR, et al. (1997). "A novel class of RanGTP binding proteins.". J. Cell Biol. 138 (1): 65–80. PMID 9214382.
Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.". EMBO J. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMID 9687515.
Paraskeva E, Izaurralde E, Bischoff FR, et al. (1999). "CRM1-mediated recycling of snurportin 1 to the cytoplasm.". J. Cell Biol. 145 (2): 255–64. PMID 10209022.
Jäkel S, Albig W, Kutay U, et al. (1999). "The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1.". EMBO J. 18 (9): 2411–23. doi:10.1093/emboj/18.9.2411. PMID 10228156.
Dean KA, von Ahsen O, Görlich D, Fried HM (2001). "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.". J. Cell. Sci. 114 (Pt 19): 3479–85. PMID 11682607.
Bäuerle M, Doenecke D, Albig W (2002). "The requirement of H1 histones for a heterodimeric nuclear import receptor.". J. Biol. Chem. 277 (36): 32480–9. doi:10.1074/jbc.M202765200. PMID 12080050.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Fassati A, Görlich D, Harrison I, et al. (2003). "Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7.". EMBO J. 22 (14): 3675–85. doi:10.1093/emboj/cdg357. PMID 12853482.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
King FW, Shtivelman E (2004). "Inhibition of nuclear import by the proapoptotic protein CC3.". Mol. Cell. Biol. 24 (16): 7091–101. doi:10.1128/MCB.24.16.7091-7101.2004. PMID 15282309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Kahle J, Baake M, Doenecke D, Albig W (2005). "Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13.". Mol. Cell. Biol. 25 (13): 5339–54. doi:10.1128/MCB.25.13.5339-5354.2005. PMID 15964792.
Arnold M, Nath A, Hauber J, Kehlenbach RH (2006). "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.". J. Biol. Chem. 281 (30): 20883–90. doi:10.1074/jbc.M602189200. PMID 16704975.
Zaitseva L, Myers R, Fassati A (2007). "tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes.". PLoS Biol. 4 (10): e332. doi:10.1371/journal.pbio.0040332. PMID 17020411.
Saijou E, Itoh T, Kim KW, et al. (2007). "Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms.". J. Biol. Chem. 282 (44): 32327–37. doi:10.1074/jbc.M706793200. PMID 17848547.