Ionomycin
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| Ionomycin | |
|---|---|
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| IUPAC name | Calcium (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-
19,21-dihydroxy-22-[(2S,5S)-5-[(2R,5S)-5- (1-hydroxyethyl)-5-methyl-2-tetrahydrofuranyl]- 5-methyl-2-tetrahydrofuranyl]-4,6,8,12,14,18,20- heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate |
| Identifiers | |
| CAS number | [56092-82-1] |
| PubChem | |
| SMILES | CC(CCC(=O)[O-])CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC
(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)[O-].[Ca+2] |
| Properties | |
| Molecular formula | C41H70CaO9 |
| Molar mass | 747.0671 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus [1]. It is used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. It is also used to stimulate the intracellular production of the cytokines interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA. These cytokines are important in the inflammatory response.
Commercially, Ionomycin can be obtained as a free acid, or as a Ca2+ salt.
[edit] References
- ^ See Ionomycin Calcium salt from Fermentek, manufacturer's product page for ionomycin
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