Ion channel family

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Ion channel (eukariotic)

Potassium channel KvAP, structure in a membrane-like environment. Calculated hydrocarbon boundaries of the lipid bilayer are indicated by red and blue dots.
Identifiers
Symbol	Ion_trans
Pfam	PF00520
InterPro	IPR005821
SCOP	1bl8
TCDB	1.A.1
OPM family	8
OPM protein	2a79
Available PDB structures: 1qg9A:157-176 2a79B:225-409 1ho7A:378-397 1ho2A:378-397 1ujlA:570-611

Ion channel (bacterial)

Potassium channel KcsA. Calculated hydrocarbon boundaries of the lipid bilayer are indicated by red and blue dots.
Identifiers
Symbol	Ion_trans_2
Pfam	PF07885
InterPro	IPR013099
SCOP	1bl8
OPM protein	1r3j
Available PDB structures: 1lnqE:25-100 2a0lB:169-250 1orqC:169-250 1k4cC:34-116 1r3iC:34-116 2bocC:34-116 1j95C:34-116 1r3lC:34-116 1jvmB:34-116 1bl8C:34-116 2a9hD:34-116 1k4dC:34-116 1r3jC:34-116 1r3kC:34-116 2bobC:34-116 1p7bB:77-151

Transmembrane ion channel family was defined in InterPro and Pfam as the family of tetrameric sodium, potassium, and calcium ion channels, in which two C-terminal transmembrane helices flank a loop which determines ion selectivity of the channel pore. This large group of ion channels apparently includes families 1.A.1, 1.A.2, 1.A.3, and 1.A.4 of transporter classification.

Many eukariotic channels have four additional transmembrane helices (TMH) (Pfam PF00520), whereas a bacterial structure of the protein has only two transmembrane helices that form the tetrameric channel (Pfam PF07885).

[edit] Human channels with 6 TM helices

CACNA1A; CACNA1B; CACNA1C; CACNA1D; CACNA1E; CACNA1F; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CATSPER1; CATSPER2; CATSPER3; CATSPER4;
CNGA1; CNGA2; CNGA3; CNGB1; CNGB3;
H1B;
HCN1; HCN2; HCN3; HCN4; HVCN1;
ITPR1; ITPR2; ITPR3;
KCNA1; KCNA10; KCNA2; KCNA3; KCNA4; KCNA5; KCNA6; KCNA7; KCNB1; KCNB2; KCNC1; KCNC2; KCNC3; KCNC4; KCND1; KCND2; KCND3; KCNF1; KCNG1; KCNG2; KCNG3; KCNG4;
KCNH1; KCNH2; KCNH3; KCNH4; KCNH5; KCNH6; KCNH7; KCNH8; KCNMA1;
KCNQ1; KCNQ2; KCNQ3; KCNQ4; KCNQ5; KCNS1; KCNS2; KCNS3; KCNV1; KCNV2;
MCOLN1; MCOLN2;MCOLN3; MLSN1; NALCN;
PKD1L3;
RCNC2; RYR1; RYR2; RYR3;
SCN10A; SCN11A; SCN1A; SCN2A; SCN2A2; SCN3A; SCN4A; SCN5A; SCN7A; SCN8A; SCN9A;
SLC9A10; SLC9A11;
TPCN1; TPCN2; TRP7; TRPA1; TRPC1; TRPC3; TRPC4; TRPC5; TRPC6; TRPC7;
TRPM1; TRPM2; TRPM3; TRPM4; TRPM5; TRPM6; TRPM7; TRPM8;
TRPV1; TRPV2; TRPV3; TRPV4; TRPV5; TRPV6; VGCNL1;

[edit] Human channels with two TM helices in each subunit, as in bacteria

KCNK1; KCNK10; KCNK12; KCNK13; KCNK15; KCNK16; KCNK17; KCNK18; KCNK2; KCNK3; KCNK4; KCNK5; KCNK6; KCNK7; KCNK9; KCNN1; KCNN2; KCNN3; KCNN4;
KCNT1; KCNT2;
SK2; SK3; SLICK;