Involucrin

From Wikipedia, the free encyclopedia

Involucrin

Identifiers

External IDs

Gene ontology
Molecular Function:	• structural molecule activity • protein binding, bridging
Cellular Component:	• cornified envelope • cytoplasm
Biological Process:	• response to UV-B • peptide cross-linking • isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine • keratinocyte differentiation • keratinization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

XM_001130659 (mRNA)
XP_001130659 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 1: 151.15 - 151.15 Mb

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Pubmed search

[1]

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Involucrin, also known as IVL, is a human gene.^[1]

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.^[1]

[edit] References

^ ^a ^b Entrez Gene: IVL involucrin.

[edit] Further reading

Eckert RL, Crish JF, Efimova T, et al. (2004). "Regulation of involucrin gene expression.". J. Invest. Dermatol. 123 (1): 13-22. doi:10.1111/j.0022-202X.2004.22723.x. PMID 15191537.
Rice RH, Green H (1980). "Presence in human epidermal cells of a soluble protein precursor of the cross-linked envelope: activation of the cross-linking by calcium ions.". Cell 18 (3): 681-94. PMID 42494.
Yaffe MB, Beegen H, Eckert RL (1992). "Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope.". J. Biol. Chem. 267 (17): 12233-8. PMID 1601889.
Simon M, Green H (1989). "The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin.". J. Biol. Chem. 263 (34): 18093-8. PMID 2461365.
Eckert RL, Green H (1986). "Structure and evolution of the human involucrin gene.". Cell 46 (4): 583-9. PMID 2873896.
Heller M, Flemington E, Kieff E, Deininger P (1985). "Repeat arrays in cellular DNA related to the Epstein-Barr virus IR3 repeat.". Mol. Cell. Biol. 5 (3): 457-65. PMID 2985954.
Welter JF, Crish JF, Agarwal C, Eckert RL (1995). "Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity.". J. Biol. Chem. 270 (21): 12614-22. PMID 7759510.
Volz A, Korge BP, Compton JG, et al. (1994). "Physical mapping of a functional cluster of epidermal differentiation genes on chromosome 1q21.". Genomics 18 (1): 92-9. doi:10.1006/geno.1993.1430. PMID 8276421.
Takahashi H, Iizuka H (1993). "Analysis of the 5'-upstream promoter region of human involucrin gene: activation by 12-O-tetradecanoylphorbol-13-acetate.". J. Invest. Dermatol. 100 (1): 10-5. PMID 8380829.
Lopez-Bayghen E, Vega A, Cadena A, et al. (1996). "Transcriptional analysis of the 5'-noncoding region of the human involucrin gene.". J. Biol. Chem. 271 (1): 512-20. PMID 8550612.
Takahashi H, Kobayashi H, Matsuo S, Iizuka H (1996). "Repression of involucrin gene expression by transcriptional enhancer factor 1 (TEF-1).". Arch. Dermatol. Res. 287 (8): 740-6. PMID 8554386.
Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope.". J. Biol. Chem. 272 (3): 2021-30. PMID 8999895.
Robinson NA, Lapic S, Welter JF, Eckert RL (1997). "S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes.". J. Biol. Chem. 272 (18): 12035-46. PMID 9115270.
Ng DC, Su MJ, Kim R, Bikle DD (2004). "Regulation of involucrin gene expression by calcium in normal human keratinocytes.". Front. Biosci. 1: a16-24. PMID 9159190.
Banks EB, Crish JF, Welter JF, Eckert RL (1998). "Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites.". Biochem. J. 331 ( Pt 1): 61-8. PMID 9512462.
Marekov LN, Steinert PM (1998). "Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope.". J. Biol. Chem. 273 (28): 17763-70. PMID 9651377.
Crish JF, Zaim TM, Eckert RL (1998). "The distal regulatory region of the human involucrin promoter is required for expression in epidermis.". J. Biol. Chem. 273 (46): 30460-5. PMID 9804813.
Lee CH, Marekov LN, Kim S, et al. (2000). "Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes.". FEBS Lett. 477 (3): 268-72. PMID 10908733.
Candi E, Oddi S, Terrinoni A, et al. (2001). "Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro.". J. Biol. Chem. 276 (37): 35014-23. doi:10.1074/jbc.M010157200. PMID 11443109.
Crish JF, Bone F, Banks EB, Eckert RL (2002). "The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation.". Oncogene 21 (5): 738-47. doi:10.1038/sj.onc.1205038. PMID 11850802.