Invadopodia

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Invadopodia or invasive feet are protrusions in the cell membrane of some cells that are rich in actin and extend into the extracellular matrix (ECM).[1] They are associated with high levels of proteolysis and cell signaling and are frequently seen in metastatic cancer cells that are invading surrounding tissues.[2] These structures are very similar to the podosomes formed by normal cells that need to cross tissue barriers, such as macrophages and monocytes, or cells such as osteoclasts that remodel tissue. However, podosomes are short-lived and do not cause major degradation of the ECM.[3]

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  1. ^ Linder S (March 2007). "The matrix corroded: podosomes and invadopodia in extracellular matrix degradation". Trends Cell Biol. 17 (3): 107–17. doi:10.1016/j.tcb.2007.01.002. PMID 17275303. 
  2. ^ Weaver AM (2006). "Invadopodia: specialized cell structures for cancer invasion". Clin. Exp. Metastasis 23 (2): 97–105. doi:10.1007/s10585-006-9014-1. PMID 16830222. 
  3. ^ Ayala I, Baldassarre M, Caldieri G, Buccione R (April 2006). "Invadopodia: a guided tour". Eur. J. Cell Biol. 85 (3-4): 159–64. doi:10.1016/j.ejcb.2005.09.005. PMID 16546558. 

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Structures of the cell membrane
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