Interleukin 8 receptor, alpha
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Interleukin 8 receptor, alpha
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| Identifiers | ||||||||||||||
| Symbol(s) | IL8RA; CKR-1; C-C; C-C CKR-1; C-C-CKR-1; CD128; CD181; CDw128a; CMKAR1; CXCR1; IL8R1; IL8RBA | |||||||||||||
| External IDs | OMIM: 146929 MGI: 2448715 HomoloGene: 68074 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3577 | 227288 | ||||||||||||
| Ensembl | ENSG00000163464 | ENSMUSG00000048480 | ||||||||||||
| Uniprot | P25024 | n/a | ||||||||||||
| Refseq | NM_000634 (mRNA) NP_000625 (protein) |
NM_178241 (mRNA) NP_839972 (protein) |
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| Location | Chr 2: 218.74 - 218.74 Mb | Chr 1: 74.12 - 74.13 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Interleukin 8 receptor, alpha is a chemokine receptor. IL8RA is its human gene.
IL8RA has also recently been designated CD181 (cluster of differentiation 181).
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.[1]
[edit] See also
[edit] References
- Ahuja SK, Ozçelik T, Milatovitch A, et al. (1993). "Molecular evolution of the human interleukin-8 receptor gene cluster.". Nat. Genet. 2 (1): 31–6. doi:. PMID 1303245.
- Lee J, Horuk R, Rice GC, et al. (1992). "Characterization of two high affinity human interleukin-8 receptors.". J. Biol. Chem. 267 (23): 16283–7. PMID 1379593.
- Morris SW, Nelson N, Valentine MB, et al. (1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.". Genomics 14 (3): 685–91. PMID 1427896.
- Holmes WE, Lee J, Kuang WJ, et al. (1991). "Structure and functional expression of a human interleukin-8 receptor.". Science 253 (5025): 1278–80. PMID 1840701.
- Chuntharapai A, Lee J, Hébert CA, Kim KJ (1995). "Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes.". J. Immunol. 153 (12): 5682–8. PMID 7527448.
- Chuntharapai A, Kim KJ (1995). "Regulation of the expression of IL-8 receptor A/B by IL-8: possible functions of each receptor.". J. Immunol. 155 (5): 2587–94. PMID 7650389.
- Morohashi H, Miyawaki T, Nomura H, et al. (1995). "Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells.". J. Leukoc. Biol. 57 (1): 180–7. PMID 7829970.
- Schönbeck U, Brandt E, Petersen F, et al. (1995). "IL-8 specifically binds to endothelial but not to smooth muscle cells.". J. Immunol. 154 (5): 2375–83. PMID 7868904.
- Ahuja SK, Shetty A, Tiffany HL, Murphy PM (1994). "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.". J. Biol. Chem. 269 (42): 26381–9. PMID 7929358.
- Sprenger H, Lloyd AR, Meyer RG, et al. (1994). "Genomic structure, characterization, and identification of the promoter of the human IL-8 receptor A gene.". J. Immunol. 153 (6): 2524–32. PMID 8077663.
- Schnitzel W, Monschein U, Besemer J (1994). "Monomer-dimer equilibria of interleukin-8 and neutrophil-activating peptide 2. Evidence for IL-8 binding as a dimer and oligomer to IL-8 receptor B.". J. Leukoc. Biol. 55 (6): 763–70. PMID 8195702.
- Wu D, LaRosa GJ, Simon MI (1993). "G protein-coupled signal transduction pathways for interleukin-8.". Science 261 (5117): 101–3. PMID 8316840.
- Sebok K, Woodside D, al-Aoukaty A, et al. (1993). "IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein.". J. Immunol. 150 (4): 1524–34. PMID 8381837.
- Cerretti DP, Kozlosky CJ, Vanden Bos T, et al. (1993). "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.". Mol. Immunol. 30 (4): 359–67. PMID 8384312.
- Mollereau C, Muscatelli F, Mattei MG, et al. (1993). "The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor.". Genomics 16 (1): 248–51. doi:. PMID 8486366.
- Lloyd A, Modi W, Sprenger H, et al. (1993). "Assignment of genes for interleukin-8 receptors (IL8R) A and B to human chromosome band 2q35.". Cytogenet. Cell Genet. 63 (4): 238–40. PMID 8500355.
- Damaj BB, McColl SR, Mahana W, et al. (1996). "Physical association of Gi2alpha with interleukin-8 receptors.". J. Biol. Chem. 271 (22): 12783–9. PMID 8662698.
- Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor.". J. Biol. Chem. 271 (34): 20545–50. PMID 8702798.
- Damaj BB, McColl SR, Neote K, et al. (1996). "Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops.". FASEB J. 10 (12): 1426–34. PMID 8903513.
- Jerva LF, Sullivan G, Lolis E (1997). "Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: sequence analysis and mutagenesis identify receptor binding epitopes.". Protein Sci. 6 (8): 1643–52. PMID 9260277.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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