Interleukin 24

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Interleukin 24
Identifiers
Symbol(s) IL24; C49A; FISP; IL-24; IL10B; MDA7; Mob-5; ST16; mda-7
External IDs OMIM: 604136 MGI: 2135548 HomoloGene: 4991
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 11009 93672
Ensembl ENSG00000162892 ENSMUSG00000026420
Uniprot Q13007 Q925S4
Refseq NM_006850 (mRNA)
NP_006841 (protein)		 NM_053095 (mRNA)
NP_444325 (protein)
Location Chr 1: 205.14 - 205.14 Mb Chr 1: 132.71 - 132.71 Mb
Pubmed search [1] [2]

Interleukin 24 (IL-24) is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as Melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called Stat-1 and Stat-3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells [1] and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer.[2] Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.[3][4] The gene for IL-24 is located on chromosome 1 in humans.[5]

[edit] References

  1. ^ Poindexter et al., Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells. Journal of Leukocyte Biology 2005, Volume 78, pages 745-752.
  2. ^ Wang M, Liang P. Interleukin-24 and its receptors. Immunology, 2005, Volume 114, pages 166-70.
  3. ^ Fisher PB, et al., mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic. Cancer Biology and Therapeutics. 2003, Volume 2, pages S23-37.
  4. ^ M. Sauane et al., Melanoma Differentiation Associated Gene-7/Interleukin-24 Promotes Tumor Cell-Specific Apoptosis through Both Secretory and Nonsecretory Pathways. Cancer Research, 2004, Volume 64, pages 2988-2993.
  5. ^ IL24 GeneCard
v • d • e
Cytokines: interleukins
IL-1 superfamily
IL-6 like/gp130 utilizing
IL-10 family
IL-10 - IL-19 - IL-20 - IL-22 - IL-24 - IL-26
Interferon type III
Common γ-chain family
IL-12 family
Other
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