Interleukin 15 receptor, alpha subunit

From Wikipedia, the free encyclopedia

Interleukin 15 receptor, alpha

PDB rendering based on 2ers.

Available structures: 2ers

Identifiers

Symbol(s)

IL15RA; MGC104179

External IDs

OMIM: 601070 MGI: 104644 HomoloGene: 1650

Gene ontology
Molecular Function:	• receptor activity • interleukin receptor activity • protein binding
Cellular Component:	• nucleus • endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• signal transduction • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002189 (mRNA)
NP_002180 (protein)

NM_008358 (mRNA)
NP_032384 (protein)

Location

Chr 10: 6.03 - 6.06 Mb

Chr 2: 11.62 - 11.65 Mb

Pubmed search

[1]

[2]

Interleukin 15 receptor, alpha subunit is a subunit of the interleukin 15 receptor. IL15RA is its human gene.^[1]

The protein encoded by this gene is a cytokine receptor that specifically binds IL15 with high affinity. The receptors of IL15 and IL2 share two subunits, the IL2R beta and IL2R gamma chains. This forms the basis of many overlapping biological activities of IL15 and IL2. The IL2 receptor requires an additional IL2-specific alpha subunit for high affinity IL2 binding. This protein is structurally related to IL2R alpha, but is capable of binding IL15 with high affinity independent of other subunits, which suggests the distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported. The full length sequences of only two variants encoding distinct isoforms are available.^[1]

[edit] References

^ ^a ^b Entrez Gene: IL15RA interleukin 15 receptor, alpha.

[edit] Further reading

Giri JG, Kumaki S, Ahdieh M, et al. (1995). "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.". EMBO J. 14 (15): 3654-63. PMID 7641685.
Jacob CO, Mykytyn K, Varcony T, Drabkin HA (1993). "Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 and to mouse chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences.". Mamm. Genome 4 (8): 435-9. PMID 8104057.
Anderson DM, Kumaki S, Ahdieh M, et al. (1996). "Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes.". J. Biol. Chem. 270 (50): 29862-9. PMID 8530383.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Dubois S, Magrangeas F, Lehours P, et al. (1999). "Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression.". J. Biol. Chem. 274 (38): 26978-84. PMID 10480910.
Pereno R, Giron-Michel J, Gaggero A, et al. (2000). "IL-15/IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha.". Oncogene 19 (45): 5153-62. doi:10.1038/sj.onc.1203873. PMID 11064452.
Mariner JM, Lantz V, Waldmann TA, Azimi N (2001). "Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site.". J. Immunol. 166 (4): 2602-9. PMID 11160322.
Asao H, Okuyama C, Kumaki S, et al. (2001). "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.". J. Immunol. 167 (1): 1-5. PMID 11418623.
Bulanova E, Budagian V, Pohl T, et al. (2002). "The IL-15R alpha chain signals through association with Syk in human B cells.". J. Immunol. 167 (11): 6292-302. PMID 11714793.
Wu TS, Lee JM, Lai YG, et al. (2002). "Reduced expression of Bcl-2 in CD8+ T cells deficient in the IL-15 receptor alpha-chain.". J. Immunol. 168 (2): 705-12. PMID 11777964.
Khan IA, Moretto M, Wei XQ, et al. (2002). "Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response.". J. Exp. Med. 195 (11): 1463-70. PMID 12045244.
Kurowska M, Rudnicka W, Maślińska D, Maśliński W (2002). "Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain.". Ann. N. Y. Acad. Sci. 966: 441-5. PMID 12114302.
Comes A, Di Carlo E, Musiani P, et al. (2002). "IFN-gamma-independent synergistic effects of IL-12 and IL-15 induce anti-tumor immune responses in syngeneic mice.". Eur. J. Immunol. 32 (7): 1914-23. doi:10.1002/1521-4141(200207)32:7<1914::AID-IMMU1914>3.0.CO;2-P. PMID 12115611.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bernard J, Harb C, Mortier E, et al. (2004). "Identification of an interleukin-15alpha receptor-binding site on human interleukin-15.". J. Biol. Chem. 279 (23): 24313-22. doi:10.1074/jbc.M312458200. PMID 15039446.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Vámosi G, Bodnár A, Vereb G, et al. (2004). "IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells.". Proc. Natl. Acad. Sci. U.S.A. 101 (30): 11082-7. doi:10.1073/pnas.0403916101. PMID 15263076.
Mortier E, Bernard J, Plet A, Jacques Y (2004). "Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist.". J. Immunol. 173 (3): 1681-8. PMID 15265897.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.