Interleukin 12 receptor, beta 2 subunit

From Wikipedia, the free encyclopedia

Interleukin 12 receptor, beta 2

Identifiers

IL12RB2; RP11-102M16.1

External IDs

OMIM: 601642 MGI: 1270861 HomoloGene: 1197

Gene ontology
Molecular Function:	• receptor activity • interleukin receptor activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cell surface receptor linked signal transduction • positive regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001559 (mRNA)
NP_001550 (protein)

XM_983347 (mRNA)
XP_988441 (protein)

Location

Chr 1: 67.55 - 67.64 Mb

Chr 6: 67.22 - 67.31 Mb

Pubmed search

[1]

[2]

Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene.^[1]

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.^[1]

[edit] References

^ ^a ^b Entrez Gene: IL12RB2 interleukin 12 receptor, beta 2.

[edit] Further reading

Airoldi I, Guglielmino R, Carra G, et al. (2002). "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes.". Haematologica 87 (4): 434–42. PMID 11940489.
Chua AO, Chizzonite R, Desai BB, et al. (1994). "Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130.". J. Immunol. 153 (1): 128–36. PMID 7911493.
Andrew SE, Goldberg YP, Kremer B, et al. (1993). "The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease.". Nat. Genet. 4 (4): 398–403. doi:10.1038/ng0893-398. PMID 8401589.
Presky DH, Yang H, Minetti LJ, et al. (1997). "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14002–7. PMID 8943050.
Zou J, Presky DH, Wu CY, Gubler U (1997). "Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases.". J. Biol. Chem. 272 (9): 6073–7. PMID 9038232.
Rogge L, Barberis-Maino L, Biffi M, et al. (1997). "Selective expression of an interleukin-12 receptor component by human T helper 1 cells.". J. Exp. Med. 185 (5): 825–31. PMID 9120388.
Yamamoto K, Kobayashi H, Miura O, et al. (1997). "Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization.". Cytogenet. Cell Genet. 77 (3-4): 257–8. PMID 9284929.
Presky DH, Minetti LJ, Gillessen S, et al. (1998). "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex.". J. Immunol. 160 (5): 2174–9. PMID 9498755.
Morton SM, Bocaccio I, Depetris D, et al. (1998). "Assignment of IL12RB2 to human chromosome 1p31.3-->p31.2 between D1S230 and D1S198.". Cytogenet. Cell Genet. 79 (3-4): 282–3. PMID 9605872.
Naeger LK, McKinney J, Salvekar A, Hoey T (1999). "Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling.". J. Biol. Chem. 274 (4): 1875–8. PMID 9890938.
Yamamoto K, Shibata F, Miura O, et al. (1999). "Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus.". Biochem. Biophys. Res. Commun. 257 (2): 400–4. doi:10.1006/bbrc.1999.0479. PMID 10198225.
Yao BB, Niu P, Surowy CS, Faltynek CR (1999). "Direct interaction of STAT4 with the IL-12 receptor.". Arch. Biochem. Biophys. 368 (1): 147–55. doi:10.1006/abbi.1999.1302. PMID 10415122.
Matsui E, Kaneko H, Fukao T, et al. (2000). "Mutations of the IL-12 receptor beta2 chain gene in atopic subjects.". Biochem. Biophys. Res. Commun. 266 (2): 551–5. doi:10.1006/bbrc.1999.1859. PMID 10600539.
van Rietschoten JG, Smits HH, Westland R, et al. (2000). "Genomic organization of the human interleukin-12 receptor beta2-chain gene.". Immunogenetics 51 (1): 30–6. PMID 10663559.
van Rietschoten JG, Smits HH, van de Wetering D, et al. (2001). "Silencer activity of NFATc2 in the interleukin-12 receptor beta 2 proximal promoter in human T helper cells.". J. Biol. Chem. 276 (37): 34509–16. doi:10.1074/jbc.M102536200. PMID 11438525.
Kim J, Uyemura K, Van Dyke MK, et al. (2001). "A role for IL-12 receptor expression and signal transduction in host defense in leprosy.". J. Immunol. 167 (2): 779–86. PMID 11441083.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Jones ML, Young JM, Huang QR, et al. (2003). "Interleukin 12-augmented T cell proliferation of peripheral blood mononuclear cells from HIV-seropositive individuals is associated with interleukin 12 receptor beta 2 upregulation.". AIDS Res. Hum. Retroviruses 19 (4): 283–92. doi:10.1089/088922203764969483. PMID 12804004.
Yamamoto K, Yamaguchi M, Miyasaka N, Miura O (2003). "SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit.". Biochem. Biophys. Res. Commun. 310 (4): 1188–93. PMID 14559241.