Interleukin 11

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Interleukin 11
Identifiers
Symbol(s) IL11; AGIF; IL-11
External IDs OMIM: 147681 MGI: 107613 HomoloGene: 535
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3589 16156
Ensembl ENSG00000095752 ENSMUSG00000004371
Uniprot P20809 Q3V0U3
Refseq NM_000641 (mRNA)
NP_000632 (protein)		 NM_008350 (mRNA)
NP_032376 (protein)
Location Chr 19: 60.57 - 60.57 Mb Chr 7: 4.38 - 4.38 Mb
Pubmed search [1] [2]

Interleukin 11 (IL-11) is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hemtaopoiesis, most notably the stimulation of megakaryocyte maturation.[1] It is also known under the names Adipogenesis inhibitory factor (AGIF)[2] and Oprelvekin.

Compared to other interleukins, IL-11 relatively under-characterized.

The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19.[3] IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of a common transmembrane signal transducer.

[edit] Functions

IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. Besides from lymphopoietic/hematopoietic and osteotrophic properties, it has functions in many tissues such as brain, gut and testis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones.

[edit] References

  1. ^ Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara RM, Leary AC, Sibley B, Clark SC, Williams DA (1990). "Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7512–6. doi:10.1073/pnas.87.19.7512. PMID 2145578. 
  2. ^ Kawashima I, Ohsumi J, Mita-Honjo K, Shimoda-Takano K, Ishikawa H, Sakakibara S, Miyadai K, Takiguchi Y (1991). "Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11". FEBS Lett. 283 (2): 199–202. doi:10.1016/0014-5793(91)80587-S. PMID 1828438. 
  3. ^ McKinley D, Wu Q, Yang-Feng T, Yang YC (1992). "Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)". Genomics 13 (3): 814–9. doi:10.1016/0888-7543(92)90158-O. PMID 1386338. 

[edit] Further reading

  • Yang YC, Yin T (1993). "Interleukin-11 and its receptor.". Biofactors 4 (1): 15–21. PMID 1292471. 
  • Bhatia M, Davenport V, Cairo MS (2007). "The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors, lymphoma, acute myeloid leukemia and bone marrow failure syndromes.". Leuk. Lymphoma 48 (1): 9–15. doi:10.1080/10428190600909115. PMID 17325843. 
  • McKinley D, Wu Q, Yang-Feng T, Yang YC (1992). "Genomic sequence and chromosomal location of human interleukin-11 gene (IL11).". Genomics 13 (3): 814–9. PMID 1386338. 
  • Kawashima I, Ohsumi J, Mita-Honjo K, et al. (1991). "Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11.". FEBS Lett. 283 (2): 199–202. PMID 1828438. 
  • Paul SR, Bennett F, Calvetti JA, et al. (1990). "Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7512–6. PMID 2145578. 
  • Wang XY, Fuhrer DK, Marshall MS, Yang YC (1996). "Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells.". J. Biol. Chem. 270 (47): 27999–8002. PMID 7499280. 
  • Chérel M, Sorel M, Lebeau B, et al. (1995). "Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11.". Blood 86 (7): 2534–40. PMID 7670098. 
  • Yamaguchi M, Miki N, Ono M, et al. (1995). "Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer.". Endocrinology 136 (3): 1072–8. PMID 7867561. 
  • Mehler MF, Rozental R, Dougherty M, et al. (1993). "Cytokine regulation of neuronal differentiation of hippocampal progenitor cells.". Nature 362 (6415): 62–5. doi:10.1038/362062a0. PMID 8383296. 
  • Morris JC, Neben S, Bennett F, et al. (1996). "Molecular cloning and characterization of murine interleukin-11.". Exp. Hematol. 24 (12): 1369–76. PMID 8913282. 
  • Neddermann P, Graziani R, Ciliberto G, Paonessa G (1997). "Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130.". J. Biol. Chem. 271 (48): 30986–91. PMID 8940087. 
  • Barton VA, Hudson KR, Heath JK (1999). "Identification of three distinct receptor binding sites of murine interleukin-11.". J. Biol. Chem. 274 (9): 5755–61. PMID 10026196. 
  • Tacken I, Dahmen H, Boisteau O, et al. (1999). "Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis.". Eur. J. Biochem. 265 (2): 645–55. PMID 10504396. 
  • Mahboubi K, Biedermann BC, Carroll JM, Pober JS (2000). "IL-11 activates human endothelial cells to resist immune-mediated injury.". J. Immunol. 164 (7): 3837–46. PMID 10725745. 
  • Barton VA, Hall MA, Hudson KR, Heath JK (2000). "Interleukin-11 signals through the formation of a hexameric receptor complex.". J. Biol. Chem. 275 (46): 36197–203. doi:10.1074/jbc.M004648200. PMID 10948192. 
  • Curti A, Tafuri A, Ricciardi MR, et al. (2002). "Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1).". Haematologica 87 (4): 373–80. PMID 11940481. 
  • Van der Meeren A, Mouthon MA, Gaugler MH, et al. (2002). "Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: interactive effect with thrombopoietin.". Radiat. Res. 157 (6): 642–9. PMID 12005542. 
  • McCloy MP, Roberts IA, Howarth LJ, et al. (2002). "Interleukin-11 levels in healthy and thrombocytopenic neonates.". Pediatr. Res. 51 (6): 756–60. PMID 12032273. 
  • Bartz H, Büning-Pfaue F, Türkel O, Schauer U (2002). "Respiratory syncytial virus induces prostaglandin E2, IL-10 and IL-11 generation in antigen presenting cells.". Clin. Exp. Immunol. 129 (3): 438–45. PMID 12197884. 
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Cytokines: interleukins
IL-1 superfamily
IL-6 like/gp130 utilizing
IL-10 family
Interferon type III
Common γ-chain family
IL-12 family
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