Interleukin-4 receptor

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Interleukin 4 receptor
PDB rendering based on 1iar.
Available structures: 1iar
Identifiers
Symbol(s)	IL4R; CD124; IL4RA
External IDs	OMIM: 147781 MGI: 105367 HomoloGene: 7784
Gene ontology Molecular Function: • receptor activity • hematopoietin/interferon-class (D200-domain) cytokine receptor activity • interleukin-4 receptor activity • receptor signaling protein activity • protein binding Cellular Component: • integral to plasma membrane • membrane Biological Process: • immune response • signal transduction
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3566	16190
Ensembl	ENSG00000077238	ENSMUSG00000030748
Uniprot	P24394	Q3U905
Refseq	NM_000418 (mRNA) NP_000409 (protein)	NM_001008700 (mRNA) NP_001008700 (protein)
Location	Chr 16: 27.26 - 27.28 Mb	Chr 7: 125.36 - 125.37 Mb
Pubmed search	[1]	[2]

Interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.^[1]

[edit] See also

• Cluster of differentiation

[edit] References

[edit] Further reading

[edit] External links

• MeSH CD124+Antigen

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