Interleukin-23 receptor

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Interleukin 23 receptor
Identifiers
Symbol(s) IL23R;
External IDs OMIM: 607562 MGI: 2181693 HomoloGene: 16930
Orthologs
Human Mouse
Entrez 149233 209590
Ensembl ENSG00000162594 ENSMUSG00000049093
Uniprot Q5VWK5 Q8K4B4
Refseq NM_144701 (mRNA)
NP_653302 (protein)		 NM_144548 (mRNA)
NP_653131 (protein)
Location Chr 1: 67.4 - 67.5 Mb Chr 6: 67.35 - 67.42 Mb
Pubmed search [1] [2]

Interleukin 23 receptor is a type I cytokine receptor. IL23R is its human gene.[1]

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.[1]

[edit] References

  1. ^ a b Entrez Gene: IL23R interleukin 23 receptor.

[edit] Further reading

  • Parham C, Chirica M, Timans J, et al. (2002). "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.". J. Immunol. 168 (11): 5699-708. PMID 12023369. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Zhang XY, Zhang HJ, Zhang Y, et al. (2006). "Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells.". Immunogenetics 57 (12): 934-43. doi:10.1007/s00251-005-0067-0. PMID 16372191. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414. 
  • Duerr RH, Taylor KD, Brant SR, et al. (2006). "A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.". Science 314 (5804): 1461-3. doi:10.1126/science.1135245. PMID 17068223. 
  • Cargill M, Schrodi SJ, Chang M, et al. (2007). "A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.". Am. J. Hum. Genet. 80 (2): 273-90. doi:10.1086/511051. PMID 17236132. 
  • Dubinsky MC, Wang D, Picornell Y, et al. (2007). "IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease.". Inflamm. Bowel Dis. 13 (5): 511-5. doi:10.1002/ibd.20126. PMID 17309073. 
  • Tremelling M, Cummings F, Fisher SA, et al. (2007). "IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease.". Gastroenterology 132 (5): 1657-64. doi:10.1053/j.gastro.2007.02.051. PMID 17484863. 
  • Cummings JR, Ahmad T, Geremia A, et al. (2007). "Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype.". Inflamm. Bowel Dis. 13 (9): 1063-8. doi:10.1002/ibd.20180. PMID 17508420. 
  • Yamazaki K, Onouchi Y, Takazoe M, et al. (2007). "Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients.". J. Hum. Genet. 52 (7): 575-83. doi:10.1007/s10038-007-0156-z. PMID 17534574. 
  • Baldassano RN, Bradfield JP, Monos DS, et al. (2007). "Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease.". Clin. Gastroenterol. Hepatol. 5 (8): 972-6. doi:10.1016/j.cgh.2007.04.024. PMID 17618837. 
  • Sánchez E, Rueda B, Callejas JL, et al. (2007). "Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus.". Tissue Antigens 70 (3): 233-7. doi:10.1111/j.1399-0039.2007.00881.x. PMID 17661912. 
  • Orozco G, Rueda B, Robledo G, et al. (2007). "Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.". Hum. Immunol. 68 (8): 681-4. doi:10.1016/j.humimm.2007.05.008. PMID 17678723. 
  • Oliver J, Rueda B, López-Nevot MA, et al. (2007). "Replication of an association between IL23R gene polymorphism with inflammatory bowel disease.". Clin. Gastroenterol. Hepatol. 5 (8): 977-81, 981.e1-2. doi:10.1016/j.cgh.2007.05.002. PMID 17678845. 
  • Raelson JV, Little RD, Ruether A, et al. (2007). "Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.". Proc. Natl. Acad. Sci. U.S.A. 104 (37): 14747-52. doi:10.1073/pnas.0706645104. PMID 17804789. 
  • Borgiani P, Perricone C, Ciccacci C, et al. (2007). "Interleukin-23R Arg381Gln is associated with susceptibility to Crohn's disease but not with phenotype in an Italian population.". Gastroenterology 133 (3): 1049-51; author reply 1051-2. doi:10.1053/j.gastro.2007.07.013. PMID 17854611. 
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