Interleukin-21 receptor

From Wikipedia, the free encyclopedia


Interleukin 21 receptor
Identifiers
Symbol(s) IL21R; MGC10967; NILR
External IDs OMIM: 605383 MGI: 1890475 HomoloGene: 11040
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 50615 60504
Ensembl ENSG00000103522 ENSMUSG00000030745
Uniprot Q9HBE5 Q3TA82
Refseq NM_021798 (mRNA)
NP_068570 (protein)		 XM_983331 (mRNA)
XP_988425 (protein)
Location Chr 16: 27.32 - 27.37 Mb Chr 7: 125.39 - 125.42 Mb
Pubmed search [1] [2]

Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene.[1]

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.[1]

[edit] References

  1. ^ a b Entrez Gene: IL21R interleukin 21 receptor.

[edit] Further reading

  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3-174. PMID 7566098. 
  • Ozaki K, Kikly K, Michalovich D, et al. (2000). "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain.". Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11439-44. doi:10.1073/pnas.200360997. PMID 11016959. 
  • Parrish-Novak J, Dillon SR, Nelson A, et al. (2000). "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.". Nature 408 (6808): 57-63. doi:10.1038/35040504. PMID 11081504. 
  • Asao H, Okuyama C, Kumaki S, et al. (2001). "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.". J. Immunol. 167 (1): 1-5. PMID 11418623. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Jüngel A, Distler JH, Kurowska-Stolarska M, et al. (2004). "Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis.". Arthritis Rheum. 50 (5): 1468-76. doi:10.1002/art.20218. PMID 15146416. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Distler JH, Jüngel A, Kowal-Bielecka O, et al. (2005). "Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis.". Arthritis Rheum. 52 (3): 856-64. doi:10.1002/art.20883. PMID 15751077. 
  • Wu Z, Kim HP, Xue HH, et al. (2005). "Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity.". Mol. Cell. Biol. 25 (22): 9741-52. doi:10.1128/MCB.25.22.9741-9752.2005. PMID 16260592. 
  • de Totero D, Meazza R, Zupo S, et al. (2006). "Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells.". Blood 107 (9): 3708-15. doi:10.1182/blood-2005-09-3535. PMID 16391014. 
  • Pène J, Guglielmi L, Gauchat JF, et al. (2007). "IFN-gamma-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R gene.". J. Immunol. 177 (8): 5006-13. PMID 17015683. 
  • Li J, Shen W, Kong K, Liu Z (2006). "Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis.". Scand. J. Immunol. 64 (5): 515-22. doi:10.1111/j.1365-3083.2006.01795.x. PMID 17032244. 
  • Asano K, Ikegami H, Fujisawa T, et al. (2007). "Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes.". Hum. Immunol. 68 (5): 384-91. doi:10.1016/j.humimm.2007.01.009. PMID 17462506. 
  • Akamatsu N, Yamada Y, Hasegawa H, et al. (2007). "High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma.". Cancer Lett. 256 (2): 196-206. doi:10.1016/j.canlet.2007.06.001. PMID 17624663. 
 This article on a gene on chromosome 16 is a stub. You can help Wikipedia by expanding it.
v • d • e
Transmembrane receptors: immune receptors
Cytokine receptor
Pattern recognition/Toll-like
Fc receptor
Lymphocyte homing receptor
other