Interleukin-1 receptor

From Wikipedia, the free encyclopedia

interleukin 1 receptor, type I
Identifiers
Symbol	IL1R1
Alt. Symbols	IL1R, IL1RA
Entrez	3554
HUGO	5993
OMIM	147810
RefSeq	NM_000877
UniProt	P14778
Other data
Locus	Chr. 2 q12

interleukin 1 receptor, type II
Identifiers
Symbol	IL1R2
Alt. Symbols	IL1RB
Entrez	7850
HUGO	5994
OMIM	147811
RefSeq	NM_173343
UniProt	P27930
Other data
Locus	Chr. 2 q12

interleukin 1 receptor accessory protein
Identifiers
Symbol	IL1RAP
Alt. Symbols	IL-1RAcP, IL1R3, C3orf13
Entrez	3556
HUGO	5995
OMIM	602626
RefSeq	NM_134470
UniProt	Q9NPH3
Other data
Locus	Chr. 3 q28

Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.^[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.^[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).^[2]

[edit] References

[edit] External links

• MeSH Receptors,+Interleukin-1

v • d • e Transmembrane receptors: immune receptors Cytokine receptor Type I: Interleukins (2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27), CSF receptors (EPO, GM-CSF, G-CSF), GH, prolactin, Oncostatin M,Leukemia inhibitory factor - common subunits (Common gamma chain, common beta chain, CSF2RB) Type II: Interleukins (10, 20, 22, 28) - interferon (-α/β, -γ) immunoglobulin superfamily: CSF1, C-kit, IL-1, IL-18 Tumor necrosis factor: CD27, CD30, CD40, CD120, Lymphotoxin β Chemokines: IL-8 (α, β), CCR1,CXCR4 Other: IL-17, TGF-beta (1, 2) Pattern recognition/Toll-like TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10 Fc receptor ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal Lymphocyte homing receptor CD44 - L-selectin - VLA-4 - LFA-1 other Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger