Interleukin-18 receptor

interleukin 18 receptor accessory protein
Identifiers
Symbol	IL18RAP
Alt. Symbols	AcPL, CD218b
Entrez	8807
HUGO	5989
OMIM	604509
RefSeq	NM_003853
UniProt	O95256
Other data
Locus	Chr. 2 p24.3-24.1

The interleukin-18 receptor (IL-18R) is an interleukin receptor of the immunoglobulin superfamily.^[1]^[2] IL-18R is a heteromeric complex comprised of alpha- and beta-chains encoded by the genes IL18R1 and IL18RAP respectively.

[edit] References

^ Sergi B, Penttila I (2004). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents 18 (1): 55–61. PMID 15323361.
^ Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T (2003). "IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction". J. Immunol. 170 (11): 5571–7. PMID 12759435.

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v • d • e Transmembrane receptors: immune receptors

Cytokine receptor	Type I: Interleukins (2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27), CSF receptors (EPO, GM-CSF, G-CSF), GH, prolactin, Oncostatin M,Leukemia inhibitory factor - common subunits (Common gamma chain, common beta chain, CSF2RB) Type II: Interleukins (10, 20, 22, 28) - interferon (-α/β, -γ) immunoglobulin superfamily: CSF1, C-kit, IL-1, IL-18 Tumor necrosis factor: CD27, CD30, CD40, CD120, Lymphotoxin β Chemokines: IL-8 (α, β), CCR1,CXCR4 Other: IL-17, TGF-beta (1, 2)

Pattern recognition/Toll-like	TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10

Fc receptor	ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal

Lymphocyte homing receptor	CD44 - L-selectin - VLA-4 - LFA-1

other	Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger