Integrin, beta 6

From Wikipedia, the free encyclopedia

Integrin, beta 6

Identifiers

External IDs

Gene ontology
Molecular Function:	• receptor activity • integrin binding • protein binding
Cellular Component:	• integrin complex • membrane • integral to membrane
Biological Process:	• inflammatory response • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000888 (mRNA)
NP_000879 (protein)

NM_021359 (mRNA)
NP_067334 (protein)

Location

Chr 2: 160.66 - 160.77 Mb

Chr 2: 60.4 - 60.52 Mb

Pubmed search

[1]

[2]

Integrin, beta 6, also known as ITGB6, is a human gene.^[1]

[edit] References

^ Entrez Gene: ITGB6 integrin, beta 6.

[edit] Further reading

Bowen JA, Hunt JS (2000). "The role of integrins in reproduction.". Proc. Soc. Exp. Biol. Med. 223 (4): 331-43. PMID 10721002.
Jiang WM, Jenkins D, Yuan Q, et al. (1992). "The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1.". Int. Immunol. 4 (9): 1031-40. PMID 1382574.
Busk M, Pytela R, Sheppard D (1992). "Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.". J. Biol. Chem. 267 (9): 5790-6. PMID 1532572.
Krissansen GW, Yuan Q, Jenkins D, et al. (1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits.". Immunogenetics 35 (1): 58-61. PMID 1729173.
Sheppard D, Rozzo C, Starr L, et al. (1990). "Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.". J. Biol. Chem. 265 (20): 11502-7. PMID 2365683.
Weinacker A, Ferrando R, Elliott M, et al. (1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways.". Am. J. Respir. Cell Mol. Biol. 12 (5): 547-56. PMID 7537970.
Huang XZ, Chen A, Agrez M, Sheppard D (1995). "A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts.". Am. J. Respir. Cell Mol. Biol. 13 (2): 245-51. PMID 7626292.
Fernández-Ruiz E, Sánchez-Madrid F (1994). "Regional localization of the human integrin beta 6 gene (ITGB6) to chromosome 2q24-q31.". Genomics 21 (3): 638-40. doi:10.1006/geno.1994.1325. PMID 7959743.
Cone RI, Weinacker A, Chen A, Sheppard D (1994). "Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts.". Cell Adhes. Commun. 2 (2): 101-13. PMID 8081887.
Weinacker A, Chen A, Agrez M, et al. (1994). "Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.". J. Biol. Chem. 269 (9): 6940-8. PMID 8120056.
Yokosaki Y, Monis H, Chen J, Sheppard D (1996). "Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.". J. Biol. Chem. 271 (39): 24144-50. PMID 8798654.
Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM (1997). "Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo.". Am. J. Physiol. 273 (1 Pt 1): L256-63. PMID 9252563.
Ostergaard K, Salter DM, Petersen J, et al. (1998). "Expression of alpha and beta subunits of the integrin superfamily in articular cartilage from macroscopically normal and osteoarthritic human femoral heads.". Ann. Rheum. Dis. 57 (5): 303-8. PMID 9741315.
Munger JS, Huang X, Kawakatsu H, et al. (1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.". Cell 96 (3): 319-28. PMID 10025398.
Wixler V, Geerts D, Laplantine E, et al. (2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.". J. Biol. Chem. 275 (43): 33669-78. doi:10.1074/jbc.M002519200. PMID 10906324.
Arihiro K, Kaneko M, Fujii S, et al. (2000). "Significance of alpha 9 beta 1 and alpha v beta 6 integrin expression in breast carcinoma.". Breast Cancer 7 (1): 19-26. PMID 11029766.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Arend LJ, Smart AM, Briggs JP (2001). "Mouse beta(6) integrin sequence, pattern of expression, and role in kidney development.". J. Am. Soc. Nephrol. 11 (12): 2297-305. PMID 11095652.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.