INTS6

From Wikipedia, the free encyclopedia

Integrator complex subunit 6

Identifiers

INTS6; INT6; DBI-1; DDX26; DDX26A; DICE1; DKFZP434B105; HDB; Notchl2

External IDs

OMIM: 604331 MGI: 1202397 HomoloGene: 8121

Gene ontology
Molecular Function:	• nucleic acid binding • transmembrane receptor activity • protein binding • ATP binding • ATP-dependent helicase activity
Cellular Component:	• nucleus • integrator complex
Biological Process:	• snRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001039937 (mRNA)
NP_001035026 (protein)

NM_008715 (mRNA)
NP_032741 (protein)

Location

Chr 13: 50.84 - 50.93 Mb

Chr 14: 61.63 - 61.72 Mb

Pubmed search

[1]

[2]

Integrator complex subunit 6, also known as INTS6, is a human gene.^[1]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: INTS6 integrator complex subunit 6.

[edit] Further reading

Buchsbaum S, Morris C, Bochard V, Jalinot P (2007). "Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.". Oncogene 26 (35): 5132-44. doi:10.1038/sj.onc.1210314. PMID 17310990.
Hernández M, Papadopoulos N, Almeida TA (2006). "Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions.". Cancer Genet. Cytogenet. 163 (1): 91-2. doi:10.1016/j.cancergencyto.2005.04.014. PMID 16271964.
Baillat D, Hakimi MA, Näär AM, et al. (2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.". Cell 123 (2): 265-76. doi:10.1016/j.cell.2005.08.019. PMID 16239144.
Röpke A, Buhtz P, Böhm M, et al. (2005). "Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer.". Oncogene 24 (44): 6667-75. doi:10.1038/sj.onc.1208824. PMID 16007164.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wieland I, Sell C, Weidle UH, Wieacker P (2005). "Ectopic expression of DICE1 suppresses tumor cell growth.". Oncol. Rep. 12 (2): 207-11. PMID 15254679.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Li WJ, Hu N, Su H, et al. (2003). "Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma.". Oncogene 22 (2): 314-8. doi:10.1038/sj.onc.1206098. PMID 12527901.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wieland I, Röpke A, Stumm M, et al. (2002). "Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells.". Oncol. Res. 12 (11-12): 491-500. PMID 11939413.
Camargo AA, Nunes DN, Samaia HB, et al. (2002). "Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12.". Braz. J. Med. Biol. Res. 34 (10): 1237-45. PMID 11593297.
Wieland I, Arden KC, Michels D, et al. (1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas.". Oncogene 18 (32): 4530-7. doi:10.1038/sj.onc.1202806. PMID 10467397.