INSM1

From Wikipedia, the free encyclopedia

Insulinoma-associated 1

Identifiers

INSM1; IA-1; IA1

External IDs

OMIM: 600010 MGI: 1859980 HomoloGene: 31080

Gene ontology
Molecular Function:	• DNA binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • cell differentiation • endocrine pancreas development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002196 (mRNA)
NP_002187 (protein)

XM_992511 (mRNA)
XP_997605 (protein)

Location

Chr 20: 20.3 - 20.3 Mb

Chr 2: 145.91 - 145.92 Mb

Pubmed search

[1]

[2]

Insulinoma-associated 1, also known as INSM1, is a human gene.^[1]

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.^[1]

[edit] References

^ ^a ^b Entrez Gene: INSM1 insulinoma-associated 1.

[edit] Further reading

Goto Y, De Silva MG, Toscani A, et al. (1992). "A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs.". J. Biol. Chem. 267 (21): 15252-7. PMID 1634555.
Lan MS, Li Q, Lu J, et al. (1994). "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1.". J. Biol. Chem. 269 (19): 14170-4. PMID 8188699.
Li Q, Notkins AL, Lan MS (1997). "Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1.". Biochem. Biophys. Res. Commun. 236 (3): 776-81. doi:10.1006/bbrc.1997.7054. PMID 9245732.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Breslin MB, Zhu M, Notkins AL, Lan MS (2002). "Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence.". Nucleic Acids Res. 30 (4): 1038-45. PMID 11842116.
Zhu M, Breslin MB, Lan MS (2002). "Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells.". Pancreas 24 (2): 139-45. PMID 11854618.
Xie J, Cai T, Zhang H, et al. (2003). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.". Genomics 80 (1): 54-61. PMID 12079283.
Breslin MB, Zhu M, Lan MS (2003). "NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system.". J. Biol. Chem. 278 (40): 38991-7. doi:10.1074/jbc.M306795200. PMID 12890672.
Liu WD, Wang HW, Muguira M, et al. (2006). "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases.". Biochem. J. 397 (1): 169-77. doi:10.1042/BJ20051669. PMID 16569215.