INSL4

From Wikipedia, the free encyclopedia

Insulin-like 4 (placenta)

Identifiers

INSL4; EPIL; PLACENTIN

External IDs

Gene ontology
Molecular Function:	• insulin-like growth factor receptor binding • hormone activity
Cellular Component:	• extracellular region • extracellular space • soluble fraction
Biological Process:	• signal transduction • cell-cell signaling • multicellular organismal development • female pregnancy • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_002195 (mRNA)
NP_002186 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 9: 5.22 - 5.23 Mb

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Pubmed search

[1]

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Insulin-like 4 (placenta), also known as INSL4, is a human gene.^[1]

INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast.^[1]

[edit] References

^ ^a ^b Entrez Gene: INSL4 insulin-like 4 (placenta).

[edit] Further reading

Chassin D, Laurent A, Janneau JL, et al. (1996). "Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta.". Genomics 29 (2): 465-70. doi:10.1006/geno.1995.9980. PMID 8666396.
Koman A, Cazaubon S, Couraud PO, et al. (1996). "Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family.". J. Biol. Chem. 271 (34): 20238-41. PMID 8702754.
Bellet D, Lavaissiere L, Mock P, et al. (1997). "Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta.". J. Clin. Endocrinol. Metab. 82 (9): 3169-72. PMID 9284764.
Veitia R, Laurent A, Quintana-Murci L, et al. (1998). "The INSL4 gene maps close to WI-5527 at 9p24.1-->p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome.". Cytogenet. Cell Genet. 81 (3-4): 275-7. PMID 9730618.
Laurent A, Rouillac C, Delezoide AL, et al. (1999). "Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues.". Mol. Reprod. Dev. 51 (2): 123-9. doi:10.1002/(SICI)1098-2795(199810)51:2<123::AID-MRD1>3.0.CO;2-S. PMID 9740319.
Janneau JL, Maldonado-Estrada J, Tachdjian G, et al. (2002). "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.". J. Clin. Endocrinol. Metab. 87 (11): 5336-9. PMID 12414911.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bièche I, Laurent A, Laurendeau I, et al. (2004). "Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element.". Biol. Reprod. 68 (4): 1422-9. doi:10.1095/biolreprod.102.010322. PMID 12606452.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Millar L, Streiner N, Webster L, et al. (2006). "Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth.". Biol. Reprod. 73 (4): 695-702. doi:10.1095/biolreprod.105.039859. PMID 15958731.