INSIG2

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Insulin induced gene 2
Identifiers
Symbol(s) INSIG2; MGC26273
External IDs OMIM: 608660 MGI: 1920249 HomoloGene: 9400
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51141 72999
Ensembl ENSG00000125629 ENSMUSG00000003721
Refseq NM_016133 (mRNA)
NP_057217 (protein)		 NM_133748 (mRNA)
NP_598509 (protein)
Location Chr 2: 118.56 - 118.58 Mb Chr 1: 123.13 - 123.16 Mb
Pubmed search [1] [2]

Insulin induced gene 2, also known as INSIG2, is a human gene.[1]

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.[1]

[edit] References

  1. ^ a b Entrez Gene: INSIG2 insulin induced gene 2.

[edit] Further reading

  • Yabe D, Brown MS, Goldstein JL (2002). "Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12753–8. doi:10.1073/pnas.162488899. PMID 12242332. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yabe D, Xia ZP, Adams CM, Rawson RB (2003). "Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16672–7. doi:10.1073/pnas.262669399. PMID 12482938. 
  • Yabe D, Komuro R, Liang G, et al. (2003). "Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.". Proc. Natl. Acad. Sci. U.S.A. 100 (6): 3155–60. doi:10.1073/pnas.0130116100. PMID 12624180. 
  • Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB (2003). "Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.". J. Biol. Chem. 278 (37): 35837–43. doi:10.1074/jbc.M306476200. PMID 12842885. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Lee JN, Gong Y, Zhang X, Ye J (2006). "Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.". Proc. Natl. Acad. Sci. U.S.A. 103 (13): 4958–63. doi:10.1073/pnas.0600422103. PMID 16549805. 
  • Gong Y, Lee JN, Brown MS, et al. (2006). "Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6154–9. doi:10.1073/pnas.0601923103. PMID 16606821. 
  • Radhakrishnan A, Ikeda Y, Kwon HJ, et al. (2007). "Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig.". Proc. Natl. Acad. Sci. U.S.A. 104 (16): 6511–8. doi:10.1073/pnas.0700899104. PMID 17428920. 
  • Lyon HN, Emilsson V, Hinney A, et al. (2007). "The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.". PLoS Genet. 3 (4): e61. doi:10.1371/journal.pgen.0030061. PMID 17465681. 
  • Kumar J, Sunkishala RR, Karthikeyan G, Sengupta S (2007). "The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.". Clin. Genet. 71 (5): 415–8. doi:10.1111/j.1399-0004.2007.00795.x. PMID 17489846. 
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