INPP5D

From Wikipedia, the free encyclopedia

Inositol polyphosphate-5-phosphatase, 145kDa

Identifiers

INPP5D; MGC104855; MGC142140; MGC142142; SHIP; SHIP1; SIP-145; hp51CN

External IDs

OMIM: 601582 MGI: 107357 HomoloGene: 4046

Gene ontology
Molecular Function:	• inositol or phosphatidylinositol phosphatase activity • inositol-polyphosphate 5-phosphatase activity
Biological Process:	• phosphate metabolic process • intracellular signaling cascade

Orthologs

Human

Mouse

n/a

Refseq

XM_929960 (mRNA)
XP_935053 (protein)

NM_010566 (mRNA)
NP_034696 (protein)

Location

n/a

Chr 1: 89.45 - 89.55 Mb

Pubmed search

[1]

[2]

Inositol polyphosphate-5-phosphatase, 145kDa, also known as INPP5D, is a human gene.^[1]

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: INPP5D inositol polyphosphate-5-phosphatase, 145kDa.

[edit] Further reading

MacDonald SM, Vonakis BM (2003). "Association of the Src homology 2 domain-containing inositol 5' phosphatase (SHIP) to releasability in human basophils.". Mol. Immunol. 38 (16-18): 1323–7. PMID 12217402.
Damen JE, Liu L, Rosten P, et al. (1996). "The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.". Proc. Natl. Acad. Sci. U.S.A. 93 (4): 1689–93. PMID 8643691.
Lioubin MN, Algate PA, Tsai S, et al. (1996). "p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.". Genes Dev. 10 (9): 1084–95. PMID 8654924.
Kavanaugh WM, Pot DA, Chin SM, et al. (1997). "Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.". Curr. Biol. 6 (4): 438–45. PMID 8723348.
Drayer AL, Pesesse X, De Smedt F, et al. (1996). "Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.". Biochem. Biophys. Res. Commun. 225 (1): 243–9. doi:10.1006/bbrc.1996.1161. PMID 8769125.
Ware MD, Rosten P, Damen JE, et al. (1996). "Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation.". Blood 88 (8): 2833–40. PMID 8874179.
Geier SJ, Algate PA, Carlberg K, et al. (1997). "The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood.". Blood 89 (6): 1876–85. PMID 9058707.
Odai H, Sasaki K, Iwamatsu A, et al. (1997). "Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.". Blood 89 (8): 2745–56. PMID 9108392.
Liu L, Damen JE, Ware MD, Krystal G (1997). "Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2.". J. Biol. Chem. 272 (17): 10998–1001. PMID 9110989.
Giuriato S, Payrastre B, Drayer AL, et al. (1997). "Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets.". J. Biol. Chem. 272 (43): 26857–63. PMID 9341117.
Kuroiwa A, Yamashita Y, Inui M, et al. (1998). "Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene.". J. Biol. Chem. 273 (2): 1070–4. PMID 9422771.
Liu Q, Shalaby F, Jones J, et al. (1998). "The SH2-containing inositol polyphosphate 5-phosphatase, ship, is expressed during hematopoiesis and spermatogenesis.". Blood 91 (8): 2753–9. PMID 9531585.
Zhang S, Broxmeyer HE (1999). "p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells.". Biochem. Biophys. Res. Commun. 254 (2): 440–5. doi:10.1006/bbrc.1998.9959. PMID 9918857.
Mikhalap SV, Shlapatska LM, Berdova AG, et al. (1999). "CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis.". J. Immunol. 162 (10): 5719–27. PMID 10229804.
Pumphrey NJ, Taylor V, Freeman S, et al. (1999). "Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31.". FEBS Lett. 450 (1-2): 77–83. PMID 10350061.
Mason JM, Beattie BK, Liu Q, et al. (2000). "The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor.". J. Biol. Chem. 275 (6): 4398–406. PMID 10660611.
Bone H, Welham MJ (2000). "Shc associates with the IL-3 receptor beta subunit, SHIP and Gab2 following IL-3 stimulation. Contribution of Shc PTB and SH2 domains.". Cell. Signal. 12 (3): 183–94. PMID 10704825.
Lemay S, Davidson D, Latour S, Veillette A (2000). "Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling.". Mol. Cell. Biol. 20 (8): 2743–54. PMID 10733577.
Poe JC, Fujimoto M, Jansen PJ, et al. (2000). "CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.". J. Biol. Chem. 275 (23): 17420–7. doi:10.1074/jbc.M001892200. PMID 10748054.
Dunant NM, Wisniewski D, Strife A, et al. (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells.". Cell. Signal. 12 (5): 317–26. PMID 10822173.