INPP5B

From Wikipedia, the free encyclopedia

Inositol polyphosphate-5-phosphatase, 75kDa

Identifiers

INPP5B; 5PTase; MGC65156; MGC71303

External IDs

OMIM: 147264 MGI: 103257 HomoloGene: 69021

Gene ontology
Molecular Function:	• phosphoinositide 5-phosphatase activity • inositol-polyphosphate 5-phosphatase activity • hydrolase activity
Cellular Component:	• intracellular • cytosol • integral to membrane
Biological Process:	• signal transduction • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_005540 (mRNA)
NP_005531 (protein)

XM_622561 (mRNA)
XP_622561 (protein)

Location

Chr 1: 38.1 - 38.19 Mb

Chr 4: 124.24 - 124.3 Mb

Pubmed search

[1]

[2]

Inositol polyphosphate-5-phosphatase, 75kDa, also known as INPP5B, is a human gene.^[1]

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa.

[edit] Further reading

Ross TS, Jefferson AB, Mitchell CA, Majerus PW (1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase.". J. Biol. Chem. 266 (30): 20283–9. PMID 1718960.
Mitchell CA, Connolly TM, Majerus PW (1989). "Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets.". J. Biol. Chem. 264 (15): 8873–7. PMID 2542294.
Jefferson AB, Majerus PW (1995). "Properties of type II inositol polyphosphate 5-phosphatase.". J. Biol. Chem. 270 (16): 9370–7. PMID 7721860.
Jänne PA, Dutra AS, Dracopoli NC, et al. (1994). "Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34.". Cytogenet. Cell Genet. 66 (3): 164–6. PMID 8125013.
Speed CJ, Matzaris M, Bird PI, Mitchell CA (1996). "Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase.". Eur. J. Biochem. 234 (1): 216–24. PMID 8529643.
Jänne PA, Rochelle JM, Martin-DeLeon PA, et al. (1996). "Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens.". Genomics 28 (2): 280–5. doi:10.1006/geno.1995.1142. PMID 8530037.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.